The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Ferric uptake regulation protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
310 A5F6G4 (/IDA) A5F6G4 (/IDA) B6EHL8 (/IDA) B6EHL8 (/IDA) B6EHL8 (/IDA) B7J425 (/IDA) B7J425 (/IDA) B8CQZ2 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA)
(300 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
304 B6EHL8 (/IDA) B6EHL8 (/IDA) B6EHL8 (/IDA) B7J425 (/IDA) B7J425 (/IDA) B8CQZ2 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA)
(294 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
285 A5F6G4 (/IMP) A5F6G4 (/IMP) B7J425 (/IMP) B7J425 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP)
(275 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
273 B7J425 (/IMP) B7J425 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP)
(263 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
267 A5F6G4 (/IPI) A5F6G4 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) P0A0S8 (/IPI)
(257 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
256 A5F6G4 (/IPI) A5F6G4 (/IPI) P0A0S8 (/IPI) P0A0S8 (/IPI) P0A0S8 (/IPI) P0A0S8 (/IPI) P0A0S8 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI)
(246 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
241 P0A0S8 (/IPI) P0A0S8 (/IPI) P0A0S8 (/IPI) P0A0S8 (/IPI) P0A0S8 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI)
(231 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
205 A5F6G4 (/IDA) A5F6G4 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA)
(195 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
188 P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA)
(178 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
187 P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI) P0A9A9 (/IPI)
(177 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
184 P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA)
(174 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
184 P0A9A9 (/IEP) P0A9A9 (/IEP) P0A9A9 (/IEP) P0A9A9 (/IEP) P0A9A9 (/IEP) P0A9A9 (/IEP) P0A9A9 (/IEP) P0A9A9 (/IEP) P0A9A9 (/IEP) P0A9A9 (/IEP)
(174 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
26 B7J425 (/IEP) B7J425 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP)
(16 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
16 B7J425 (/IEP) B7J425 (/IEP) Q03456 (/IEP) Q03456 (/IEP) Q03456 (/IEP) Q03456 (/IEP) Q03456 (/IEP) Q03456 (/IEP) Q03456 (/IEP) Q03456 (/IEP)
(6 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
15 A5F6G4 (/IMP) A5F6G4 (/IMP) P33117 (/IMP) P33117 (/IMP) P33117 (/IMP) Q8PAL3 (/IMP) Q8PAL3 (/IMP) Q8PAL3 (/IMP) Q8PAL3 (/IMP) Q8PAL3 (/IMP)
(5 more)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
12 Q03456 (/TAS) Q03456 (/TAS) Q03456 (/TAS) Q03456 (/TAS) Q03456 (/TAS) Q03456 (/TAS) Q03456 (/TAS) Q03456 (/TAS) Q03456 (/TAS) Q03456 (/TAS)
(2 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
12 Q8KLU1 (/IPI) Q8KLU1 (/IPI) Q8KLU1 (/IPI) Q8KLU1 (/IPI) Q8KLU1 (/IPI) Q8KLU1 (/IPI) Q8KLU1 (/IPI) Q8KLU1 (/IPI) Q8KLU1 (/IPI) Q8KLU1 (/IPI)
(2 more)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
12 Q03456 (/IDA) Q03456 (/IDA) Q03456 (/IDA) Q03456 (/IDA) Q03456 (/IDA) Q03456 (/IDA) Q03456 (/IDA) Q03456 (/IDA) Q03456 (/IDA) Q03456 (/IDA)
(2 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
10 P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
4 Q5F5Y9 (/EXP) Q5F5Y9 (/EXP) Q5F5Y9 (/EXP) Q5F5Y9 (/EXP)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
4 Q5F5Y9 (/EXP) Q5F5Y9 (/EXP) Q5F5Y9 (/EXP) Q5F5Y9 (/EXP)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
4 Q5F5Y9 (/EXP) Q5F5Y9 (/EXP) Q5F5Y9 (/EXP) Q5F5Y9 (/EXP)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
4 Q5F5Y9 (/IMP) Q5F5Y9 (/IMP) Q5F5Y9 (/IMP) Q5F5Y9 (/IMP)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
225 A5F6G4 (/IEP) A5F6G4 (/IEP) B6EHL8 (/IEP) B6EHL8 (/IEP) B6EHL8 (/IEP) B7J425 (/IEP) B7J425 (/IEP) P0A0S8 (/IEP) P0A0S8 (/IEP) P0A0S8 (/IEP)
(215 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
198 B3H1Z1 (/IDA) B3H1Z1 (/IDA) B3H1Z1 (/IDA) B3H1Z1 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA)
(188 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
46 B7J425 (/EXP) B7J425 (/EXP) B8CQZ2 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP) P33086 (/EXP) P33086 (/EXP)
(36 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
36 A5F6G4 (/EXP) A5F6G4 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP) P0A3E5 (/EXP) P0A3E5 (/EXP) P0A3E5 (/EXP)
(26 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
15 B7J425 (/IDA) B7J425 (/IDA) P33117 (/IDA) P33117 (/IDA) P33117 (/IDA) Q8PAL3 (/IDA) Q8PAL3 (/IDA) Q8PAL3 (/IDA) Q8PAL3 (/IDA) Q8PAL3 (/IDA)
(5 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
13 A3N1M0 (/IEP) A3N1M0 (/IEP) A3N1M0 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP)
(3 more)
Siderophore biosynthetic process GO:0019290
The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
12 Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP)
(2 more)
Negative regulation of lyase activity GO:0051350
Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
12 Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP)
(2 more)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
12 H7C6K3 (/EXP) H7C6K3 (/EXP) H7C6K3 (/EXP) H7C6K3 (/EXP) H7C6K3 (/EXP) H7C6K3 (/EXP) H7C6K3 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP)
(2 more)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
12 H7C6K3 (/IEP) H7C6K3 (/IEP) H7C6K3 (/IEP) H7C6K3 (/IEP) H7C6K3 (/IEP) H7C6K3 (/IEP) H7C6K3 (/IEP) P0A0S8 (/IEP) P0A0S8 (/IEP) P0A0S8 (/IEP)
(2 more)
Negative regulation of siderophore biosynthetic process GO:1900705
Any process that stops, prevents or reduces the frequency, rate or extent of siderophore biosynthetic process.
12 Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP)
(2 more)
Regulation of superoxide dismutase activity GO:1901668
Any process that modulates the frequency, rate or extent of superoxide dismutase activity.
12 Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP)
(2 more)
Positive regulation of peroxidase activity GO:2000470
Any process that activates or increases the frequency, rate or extent of peroxidase activity.
12 Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP) Q03456 (/IMP)
(2 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
9 B7J425 (/IDA) B7J425 (/IDA) H7C6K3 (/IDA) H7C6K3 (/IDA) H7C6K3 (/IDA) H7C6K3 (/IDA) H7C6K3 (/IDA) H7C6K3 (/IDA) H7C6K3 (/IDA)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
7 H7C6K3 (/IDA) H7C6K3 (/IDA) H7C6K3 (/IDA) H7C6K3 (/IDA) H7C6K3 (/IDA) H7C6K3 (/IDA) H7C6K3 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
5 P0A0S8 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP) P0A0S8 (/EXP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
5 P0A0S8 (/IEP) P0A0S8 (/IEP) P0A0S8 (/IEP) P0A0S8 (/IEP) P0A0S8 (/IEP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
310 A5F6G4 (/IDA) A5F6G4 (/IDA) B6EHL8 (/IDA) B6EHL8 (/IDA) B6EHL8 (/IDA) B7J425 (/IDA) B7J425 (/IDA) B8CQZ2 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA)
(300 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
289 A5F6G4 (/IMP) A5F6G4 (/IMP) B7J425 (/IMP) B7J425 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP) P0A9A9 (/IMP)
(279 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
267 A5F6G4 (/IPI) A5F6G4 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) H7C6K3 (/IPI) P0A0S8 (/IPI)
(257 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
210 B7J425 (/IEP) B7J425 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP) P0A3E5 (/IEP)
(200 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
184 P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA) P0A9A9 (/IDA)
(174 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
4 Q5F5Y9 (/EXP) Q5F5Y9 (/EXP) Q5F5Y9 (/EXP) Q5F5Y9 (/EXP)
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