The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 27: Heat shock transcription factor 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 67 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
22 A0A060W590 (/IDA) A0A096MK39 (/IDA) A0A2R8QAT5 (/IDA) D0VYS2 (/IDA) F6P697 (/IDA) P38529 (/IDA) P38531 (/IDA) P38532 (/IDA) P38532 (/IDA) P38533 (/IDA)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 Q00613 (/ISA) Q03933 (/ISA) Q03933 (/ISA) Q03933 (/ISA) Q9ULV5 (/ISA) Q9ULV5 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 Q00613 (/ISM) Q03933 (/ISM) Q03933 (/ISM) Q03933 (/ISM) Q9ULV5 (/ISM) Q9ULV5 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 Q00613 (/NAS) Q03933 (/NAS) Q03933 (/NAS) Q03933 (/NAS) Q9ULV5 (/NAS) Q9ULV5 (/NAS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
6 P38529 (/IDA) P38531 (/IDA) P38532 (/IDA) P38532 (/IDA) P38533 (/IDA) Q00613 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
6 Q00613 (/TAS) Q03933 (/TAS) Q03933 (/TAS) Q03933 (/TAS) Q9ULV5 (/TAS) Q9ULV5 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
6 A0A1D5PC94 (/IDA) P38529 (/IDA) P38530 (/IDA) P38531 (/IDA) P38533 (/IDA) Q76M53 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
5 P38532 (/IDA) P38532 (/IDA) P38533 (/IDA) Q00613 (/IDA) Q02953 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P38531 (/IPI) Q00613 (/IPI) Q03933 (/IPI) Q03933 (/IPI) Q03933 (/IPI)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
Showing 1 to 10 of 67 entries

There are 169 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
9 F1MAF1 (/IDA) F6P697 (/IDA) P38529 (/IDA) P38531 (/IDA) Q1LXV0 (/IDA) Q8UWM7 (/IDA) Q90YY9 (/IDA) Q9IAS0 (/IDA) Q9IAS1 (/IDA)
Protein homotrimerization GO:0070207
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
9 A0A1D5PC94 (/IDA) P38529 (/IDA) P38530 (/IDA) P38531 (/IDA) Q00613 (/IDA) Q76M53 (/IDA) Q76M54 (/IDA) Q9R0L1 (/IDA) Q9R0L1 (/IDA)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
6 F6P697 (/IMP) Q1LXV0 (/IMP) Q8UWM7 (/IMP) Q90YY9 (/IMP) Q9IAS0 (/IMP) Q9IAS1 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
6 D0VYS2 (/IDA) Q00613 (/IDA) Q02953 (/IDA) Q03933 (/IDA) Q03933 (/IDA) Q03933 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
5 P38529 (/IMP) P38531 (/IMP) Q00613 (/IMP) Q9R0L1 (/IMP) Q9R0L1 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
Regulation of protein heterodimerization activity GO:0043497
Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
Showing 1 to 10 of 169 entries

There are 49 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 A0A096MK39 (/IDA) A0A1D5PC94 (/IDA) D0VYS2 (/IDA) F1MAF1 (/IDA) P10961 (/IDA) P10961 (/IDA) P38529 (/IDA) P38530 (/IDA) P38531 (/IDA) P38532 (/IDA)
(4 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 A0A1D5PC94 (/IDA) D0VYS2 (/IDA) F1MAF1 (/IDA) P38529 (/IDA) P38530 (/IDA) P38531 (/IDA) P38532 (/IDA) P38532 (/IDA) P38533 (/IDA) Q00613 (/IDA)
(1 more)
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 E9PMQ6 (/IDA) Q00613 (/IDA) Q03933 (/IDA) Q03933 (/IDA) Q03933 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
5 A0A024R6X7 (/IDA) A0A024R6X7 (/IDA) E5RK26 (/IDA) Q9ULV5 (/IDA) Q9ULV5 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
Nuclear stress granule GO:0097165
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
5 P38529 (/ISS) P38532 (/ISS) P38532 (/ISS) Q08DJ8 (/ISS) Q08DJ8 (/ISS)
Showing 1 to 10 of 49 entries
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