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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 213: Coniferyl alcohol 9-O-methyltransferase

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase. [EC: 2.1.1.212]
S-adenosyl-L-methionine + 2,4',7-trihydroxyisoflavanone = S-adenosyl-L- homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone.
  • Specifically methylates 2,4',7-trihydroxyisoflavanone on the 4'-position.
  • No activity with isoflavones.
  • The enzyme is involved in formononetin biosynthesis in legumes.
  • The protein from pea (Pisum sativum) also methylates (+)- 6a-hydroxymaackiain at the 3-position (cf. EC 2.1.1.270).
 5 I3RZV3 I3RZV3 Q84KK4 Q84KK4 Q84KK6
Isoflavone 4'-O-methyltransferase. [EC: 2.1.1.46]
S-adenosyl-L-methionine + a 4'-hydroxyisoflavone = S-adenosyl-L- homocysteine + a 4'-methoxyisoflavone.
  • The enzyme catalyzes the methylation of daidzein and genistein.
  • It does not methylate naringenin, apigenin, luteolin or kaempferol.
 5 I3RZV3 I3RZV3 Q84KK4 Q84KK4 Q84KK6
Tabersonine 16-O-methyltransferase. [EC: 2.1.1.94]
S-adenosyl-L-methionine + 16-hydroxytabersonine = S-adenosyl-L- homocysteine + 16-methoxytabersonine.
  • Involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle, Catharanthus roseus.
 1 B0EXJ8
Isoflavone 7-O-methyltransferase. [EC: 2.1.1.150]
S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L- homocysteine + a 7-methoxyisoflavone.
  • The enzyme from alfalfa can methylate daidzein, genistein and 6,7,4'-trihydroxyisoflavone but not flavones or flavanones.
 1 Q84KK5
Flavonoid 3',5'-methyltransferase. [EC: 2.1.1.267]
(1) S-adenosyl-L-methionine + a 3'-hydroxyflavonoid = S-adenosyl-L- homocysteine + a 3'-methoxyflavonoid. (2) S-adenosyl-L-methionine + a 5'-hydroxy-3'-methoxyflavonoid = S-adenosyl-L-homocysteine + a 3',5'-dimethoxyflavonoid.
  • Isolated from Vitis vinifera (grape).
  • Most active with delphinidin 3-glucoside but also acts on cyanidin 3-glucoside, cyanidin, myricetin, quercetin and quercetin 3-glucoside.
  • The enzyme from Catharanthus roseus was most active with myricetin.
  • Formerly EC 2.1.1.149.
 1 Q8GSN1
(R,S)-reticuline 7-O-methyltransferase. [EC: 2.1.1.291]
(1) S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-laudanine. (2) S-adenosyl-L-methionine + (R)-reticuline = S-adenosyl-L-homocysteine + (R)-laudanine.
  • The enzyme from the plant Papaver somniferum (opium poppy) methylates (S)- and (R)-reticuline with equal efficiency and is involved in the biosynthesis of tetrahydrobenzylisoquinoline alkaloids.
 1 Q6WUC2
Flavonoid 4'-O-methyltransferase. [EC: 2.1.1.231]
S-adenosyl-L-methionine + a 4'-hydroxyflavanone = S-adenosyl-L- homocysteine + a 4'-methoxyflavanone.
  • The enzyme catalyzes the 4'-methylation of naringenin.
  • In vitro it catalyzes the 4'-methylation of apigenin, quercetin, daidzein and genistein.
 1 C6TAY1
8-hydroxyquercetin 8-O-methyltransferase. [EC: 2.1.1.88]
S-adenosyl-L-methionine + 3,3',4',5,7,8-hexahydroxyflavone = S-adenosyl- L-homocysteine + 3,3',4',5,7-pentahydroxy-8-methoxyflavone.
  • Also acts on 8-hydroxykaempferol, but not on the glycosides of 8-hydroxyflavonols.
  • An enzyme from the flower buds of Lotus corniculatus.
 1 Q6VMW0
Trans-resveratrol di-O-methyltransferase. [EC: 2.1.1.240]
2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L- homocysteine + pterostilbene.
  • The enzyme catalyzes the biosynthesis of pterostilbene from resveratrol.
 1 B6VJS4
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