CATH Superfamily 1.10.10.10

FunFam 16: Forkhead box protein I1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 56 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
DNA-binding transcription factor activity GO:0003700 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.	24	P58012 (/ISS) P58012 (/ISS) Q12952 (/ISS) Q32NP8 (/ISS) Q32NP8 (/ISS) Q4VUF1 (/ISS) Q5J7N5 (/ISS) Q5J7N5 (/ISS) Q61572 (/ISS) Q61850 (/ISS) (14 more)
DNA binding GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).	17	O43638 (/ISS) O88470 (/ISS) O88470 (/ISS) Q32NP8 (/ISS) Q32NP8 (/ISS) Q4VUF1 (/ISS) Q5J7N5 (/ISS) Q5J7N5 (/ISS) Q61572 (/ISS) Q68F77 (/ISS) (7 more)
DNA-binding transcription factor activity GO:0003700 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.	17	O88470 (/IDA) O88470 (/IDA) Q12948 (/IDA) Q12948 (/IDA) Q12951 (/IDA) Q12951 (/IDA) Q5H7C2 (/IDA) Q61572 (/IDA) Q61850 (/IDA) Q61850 (/IDA) (7 more)
Sequence-specific DNA binding GO:0043565 Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.	15	Q12951 (/ISS) Q12951 (/ISS) Q28D67 (/ISS) Q61572 (/ISS) Q61850 (/ISS) Q61850 (/ISS) Q6NVT7 (/ISS) Q6P2Z3 (/ISS) Q6P8A3 (/ISS) Q7ZYQ0 (/ISS) (5 more)
DNA binding GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).	14	O88470 (/IDA) O88470 (/IDA) P32027 (/IDA) P32027 (/IDA) P58012 (/IDA) P58012 (/IDA) Q12948 (/IDA) Q12948 (/IDA) Q12952 (/IDA) Q61574 (/IDA) (4 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.	11	A8MTJ6 (/ISM) O43638 (/ISM) P58012 (/ISM) P58012 (/ISM) Q12948 (/ISM) Q12948 (/ISM) Q12951 (/ISM) Q12951 (/ISM) Q12952 (/ISM) Q6ZQN5 (/ISM) (1 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.	10	O43638 (/ISA) P58012 (/ISA) P58012 (/ISA) Q12948 (/ISA) Q12948 (/ISA) Q12951 (/ISA) Q12951 (/ISA) Q12952 (/ISA) Q6ZQN5 (/ISA) Q99958 (/ISA)
Cysteine-type endopeptidase regulator activity involved in apoptotic process GO:0043028 Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.	10	O88470 (/ISS) O88470 (/ISS) Q4VUF1 (/ISS) Q5J7N5 (/ISS) Q5J7N5 (/ISS) Q6VFT5 (/ISS) Q6VFT6 (/ISS) Q6VFT6 (/ISS) Q6VFT7 (/ISS) Q8MIP2 (/ISS)
Transcription regulatory region DNA binding GO:0044212 Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.	10	Q12948 (/ISS) Q12948 (/ISS) Q12951 (/ISS) Q12951 (/ISS) Q32NP8 (/ISS) Q32NP8 (/ISS) Q68F77 (/ISS) Q99958 (/ISS) Q9PVZ3 (/ISS) Q9PVZ3 (/ISS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.	8	O88470 (/IDA) O88470 (/IDA) Q12951 (/IDA) Q12951 (/IDA) Q61574 (/IDA) Q61574 (/IDA) Q922I5 (/IDA) Q99958 (/IDA)
Sequence-specific DNA binding GO:0043565 Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.	8	Q12948 (/IDA) Q12948 (/IDA) Q12952 (/IDA) Q61572 (/IDA) Q91904 (/IDA) Q91904 (/IDA) Q922I5 (/IDA) Q99958 (/IDA)
Promoter-specific chromatin binding GO:1990841 Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.	8	Q12948 (/ISS) Q12948 (/ISS) Q63246 (/ISS) Q6NVT7 (/ISS) Q99958 (/ISS) Q9PVY8 (/ISS) Q9PVY9 (/ISS) Q9PVY9 (/ISS)
Protein binding GO:0005515 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	7	O88470 (/IPI) O88470 (/IPI) P58012 (/IPI) P58012 (/IPI) Q12948 (/IPI) Q12948 (/IPI) Q99958 (/IPI)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.	6	O88470 (/IDA) O88470 (/IDA) Q12951 (/IDA) Q12951 (/IDA) Q922I5 (/IDA) Q99958 (/IDA)
DNA binding GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).	6	O88470 (/ISO) O88470 (/ISO) Q61572 (/ISO) Q61850 (/ISO) Q61850 (/ISO) Q64731 (/ISO)
Transcription regulatory region DNA binding GO:0044212 Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.	6	Q12948 (/IDA) Q12948 (/IDA) Q61572 (/IDA) Q61850 (/IDA) Q61850 (/IDA) Q922I5 (/IDA)
DNA binding GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).	5	Q91905 (/NAS) Q91905 (/NAS) Q9PVY8 (/NAS) Q9PVY9 (/NAS) Q9PVY9 (/NAS)
DNA-binding transcription factor activity GO:0003700 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.	5	P58012 (/NAS) P58012 (/NAS) Q9PVY8 (/NAS) Q9PVY9 (/NAS) Q9PVY9 (/NAS)
DNA-binding transcription factor activity GO:0003700 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.	5	O43638 (/TAS) O88470 (/TAS) O88470 (/TAS) Q63248 (/TAS) Q64731 (/TAS)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.	4	Q12948 (/NAS) Q12948 (/NAS) Q12951 (/NAS) Q12951 (/NAS)
DNA-binding transcription factor activity GO:0003700 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.	4	Q12948 (/IMP) Q12948 (/IMP) Q61850 (/IMP) Q61850 (/IMP)
DNA-binding transcription factor activity GO:0003700 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.	4	Q61572 (/ISO) Q61850 (/ISO) Q61850 (/ISO) Q922I5 (/ISO)
Sequence-specific DNA binding GO:0043565 Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.	4	Q61572 (/ISO) Q61850 (/ISO) Q61850 (/ISO) Q64731 (/ISO)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.	3	Q12948 (/IDA) Q12948 (/IDA) Q99958 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.	3	Q61572 (/ISO) Q61850 (/ISO) Q61850 (/ISO)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.	3	Q61850 (/ISO) Q61850 (/ISO) Q922I5 (/ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.	3	Q61850 (/ISO) Q61850 (/ISO) Q922I5 (/ISO)
Transcription factor binding GO:0008134 Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.	3	Q12948 (/IPI) Q12948 (/IPI) Q61572 (/IPI)
DNA binding, bending GO:0008301 The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.	3	Q12951 (/NAS) Q12951 (/NAS) Q12952 (/NAS)
Chromatin DNA binding GO:0031490 Interacting selectively and non-covalently with DNA that is assembled into chromatin.	3	Q61850 (/ISS) Q61850 (/ISS) Q6NVT7 (/ISS)
Promoter-specific chromatin binding GO:1990841 Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.	3	Q61572 (/IDA) Q61850 (/IDA) Q61850 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.	2	Q61850 (/IGI) Q61850 (/IGI)
Transcription coactivator binding GO:0001223 Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.	2	Q12948 (/ISS) Q12948 (/ISS)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.	2	Q61574 (/IDA) Q61574 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.	2	Q12948 (/IC) Q12948 (/IC)
DNA binding GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).	2	P58012 (/TAS) P58012 (/TAS)
Transcription coactivator activity GO:0003713 A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.	2	Q12948 (/ISS) Q12948 (/ISS)
DNA binding, bending GO:0008301 The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.	2	Q12948 (/IDA) Q12948 (/IDA)
Estrogen receptor binding GO:0030331 Interacting selectively and non-covalently with an estrogen receptor.	2	O88470 (/IPI) O88470 (/IPI)
Chromatin DNA binding GO:0031490 Interacting selectively and non-covalently with DNA that is assembled into chromatin.	2	Q61850 (/ISO) Q61850 (/ISO)
Ubiquitin conjugating enzyme binding GO:0031624 Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.	2	P58012 (/IPI) P58012 (/IPI)
Ubiquitin conjugating enzyme binding GO:0031624 Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.	2	O88470 (/ISO) O88470 (/ISO)
Identical protein binding GO:0042802 Interacting selectively and non-covalently with an identical protein or proteins.	2	Q61850 (/ISO) Q61850 (/ISO)
Cysteine-type endopeptidase regulator activity involved in apoptotic process GO:0043028 Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.	2	P58012 (/IMP) P58012 (/IMP)
Cysteine-type endopeptidase regulator activity involved in apoptotic process GO:0043028 Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.	2	O88470 (/ISO) O88470 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.	1	Q61572 (/IDA)
Transcription coactivator binding GO:0001223 Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.	1	Q61572 (/IMP)
Chromatin binding GO:0003682 Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.	1	Q9DE25 (/IDA)
Transcription coactivator activity GO:0003713 A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.	1	Q61572 (/IMP)
Transcription factor binding GO:0008134 Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.	1	Q61572 (/ISO)
Transcription factor binding GO:0008134 Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.	1	Q61572 (/ISS)
DNA binding, bending GO:0008301 The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.	1	Q61572 (/ISO)
DNA binding, bending GO:0008301 The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.	1	Q61572 (/ISS)
Chromatin DNA binding GO:0031490 Interacting selectively and non-covalently with DNA that is assembled into chromatin.	1	Q99958 (/IDA)
Identical protein binding GO:0042802 Interacting selectively and non-covalently with an identical protein or proteins.	1	Q99958 (/IPI)
Transcription regulatory region DNA binding GO:0044212 Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.	1	Q61572 (/ISO)

There are 251 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Positive regulation of transcription, DNA-templated GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.	27	P58012 (/ISS) P58012 (/ISS) Q28D67 (/ISS) Q4VUF1 (/ISS) Q5J7N5 (/ISS) Q5J7N5 (/ISS) Q61572 (/ISS) Q61850 (/ISS) Q61850 (/ISS) Q6NVT7 (/ISS) (17 more)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	17	Q12948 (/ISS) Q12948 (/ISS) Q32NP8 (/ISS) Q32NP8 (/ISS) Q63246 (/ISS) Q68F77 (/ISS) Q6NVT7 (/ISS) Q6VFT6 (/ISS) Q6VFT6 (/ISS) Q6VFT7 (/ISS) (7 more)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	11	O88470 (/IDA) O88470 (/IDA) Q12948 (/IDA) Q12948 (/IDA) Q12951 (/IDA) Q12951 (/IDA) Q61572 (/IDA) Q61850 (/IDA) Q61850 (/IDA) Q922I5 (/IDA) (1 more)
Ovarian follicle development GO:0001541 The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.	10	O88470 (/ISS) O88470 (/ISS) P58012 (/ISS) P58012 (/ISS) Q4VUF1 (/ISS) Q6VFT5 (/ISS) Q6VFT6 (/ISS) Q6VFT6 (/ISS) Q6VFT7 (/ISS) Q8MIP2 (/ISS)
Apoptotic DNA fragmentation GO:0006309 The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.	10	O88470 (/ISS) O88470 (/ISS) Q4VUF1 (/ISS) Q5J7N5 (/ISS) Q5J7N5 (/ISS) Q6VFT5 (/ISS) Q6VFT6 (/ISS) Q6VFT6 (/ISS) Q6VFT7 (/ISS) Q8MIP2 (/ISS)
Positive regulation of apoptotic process GO:0043065 Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.	10	O88470 (/ISS) O88470 (/ISS) Q4VUF1 (/ISS) Q5J7N5 (/ISS) Q5J7N5 (/ISS) Q6VFT5 (/ISS) Q6VFT6 (/ISS) Q6VFT6 (/ISS) Q6VFT7 (/ISS) Q8MIP2 (/ISS)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.	10	O88470 (/ISS) O88470 (/ISS) Q4VUF1 (/ISS) Q5J7N5 (/ISS) Q5J7N5 (/ISS) Q6VFT5 (/ISS) Q6VFT6 (/ISS) Q6VFT6 (/ISS) Q6VFT7 (/ISS) Q8MIP2 (/ISS)
Extraocular skeletal muscle development GO:0002074 The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.	8	O88470 (/ISS) O88470 (/ISS) Q4VUF1 (/ISS) Q6VFT5 (/ISS) Q6VFT6 (/ISS) Q6VFT6 (/ISS) Q6VFT7 (/ISS) Q8MIP2 (/ISS)
Epidermal cell fate specification GO:0009957 The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.	8	A3KNJ3 (/IMP) B3DGC2 (/IMP) F1R746 (/IMP) Q6DG75 (/IMP) Q7T1C0 (/IMP) Q7T1C1 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.	7	Q12948 (/IDA) Q12948 (/IDA) Q61850 (/IDA) Q61850 (/IDA) Q8MIP2 (/IDA) Q922I5 (/IDA) Q99958 (/IDA)
Chemokine-mediated signaling pathway GO:0070098 A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.	7	Q12948 (/ISS) Q12948 (/ISS) Q32NP8 (/ISS) Q32NP8 (/ISS) Q68F77 (/ISS) Q9PVZ3 (/ISS) Q9PVZ3 (/ISS)
Cellular response to chemokine GO:1990869 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.	7	Q12948 (/ISS) Q12948 (/ISS) Q32NP8 (/ISS) Q32NP8 (/ISS) Q68F77 (/ISS) Q9PVZ3 (/ISS) Q9PVZ3 (/ISS)
Regulation of transcription, DNA-templated GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.	6	Q32NP8 (/ISS) Q32NP8 (/ISS) Q61572 (/ISS) Q68F77 (/ISS) Q9PVZ3 (/ISS) Q9PVZ3 (/ISS)
Heart development GO:0007507 The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.	6	Q12952 (/IMP) Q61572 (/IMP) Q61850 (/IMP) Q61850 (/IMP) Q99958 (/IMP) Q9DE25 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.	6	P58012 (/IDA) P58012 (/IDA) Q5H7C2 (/IDA) Q61574 (/IDA) Q61574 (/IDA) Q7SY22 (/IDA)
Ovarian follicle development GO:0001541 The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.	5	O88470 (/IMP) O88470 (/IMP) P58012 (/IMP) P58012 (/IMP) Q61572 (/IMP)
Blood vessel development GO:0001568 The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.	5	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI) Q9DE24 (/IGI) Q9DE25 (/IGI)
Regulation of transcription, DNA-templated GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.	5	Q12948 (/IDA) Q12948 (/IDA) Q6DG75 (/IDA) Q7T2N8 (/IDA) Q804B2 (/IDA)
Mesoderm development GO:0007498 The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.	5	Q32NP8 (/ISS) Q32NP8 (/ISS) Q68F77 (/ISS) Q6NVT7 (/ISS) Q9PVY8 (/ISS)
Epidermal cell fate specification GO:0009957 The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.	5	A3KNJ3 (/IDA) B3DGC2 (/IDA) F1R746 (/IDA) Q7T1C0 (/IDA) Q7T1C1 (/IDA)
Epidermal cell fate specification GO:0009957 The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.	5	A3KNJ3 (/IGI) B3DGC2 (/IGI) F1R746 (/IGI) Q7T1C0 (/IGI) Q7T1C1 (/IGI)
Camera-type eye development GO:0043010 The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.	5	A0A2R8QK25 (/IGI) Q6NY62 (/IGI) Q7T1C2 (/IGI) Q9DE24 (/IGI) Q9DE25 (/IGI)
Camera-type eye development GO:0043010 The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.	5	Q5H7C2 (/IMP) Q61572 (/IMP) Q61850 (/IMP) Q61850 (/IMP) Q7SY22 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	5	Q12948 (/IMP) Q12948 (/IMP) Q61572 (/IMP) Q61850 (/IMP) Q61850 (/IMP)
Embryonic viscerocranium morphogenesis GO:0048703 The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.	5	Q61850 (/IMP) Q61850 (/IMP) Q6DG75 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Negative regulation of cold-induced thermogenesis GO:0120163 Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.	5	B9EI61 (/ISS) B9EI61 (/ISS) Q61850 (/ISS) Q61850 (/ISS) Q63246 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122 Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.	4	Q61574 (/IDA) Q61574 (/IDA) Q61850 (/IDA) Q61850 (/IDA)
Ectoderm development GO:0007398 The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.	4	Q91904 (/IMP) Q91904 (/IMP) Q91905 (/IMP) Q91905 (/IMP)
Heart development GO:0007507 The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.	4	Q61572 (/ISO) Q61850 (/ISO) Q61850 (/ISO) Q64731 (/ISO)
Cell population proliferation GO:0008283 The multiplication or reproduction of cells, resulting in the expansion of a cell population.	4	Q12948 (/IMP) Q12948 (/IMP) Q61850 (/IMP) Q61850 (/IMP)
Female somatic sex determination GO:0019101 The determination of sex and sexual phenotypes in a female organism's soma.	4	Q6VFT6 (/ISS) Q6VFT6 (/ISS) Q6VFT7 (/ISS) Q8MIP2 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	4	Q61572 (/ISO) Q61850 (/ISO) Q61850 (/ISO) Q922I5 (/ISO)
Embryonic eye morphogenesis GO:0048048 The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.	4	O88470 (/IMP) O88470 (/IMP) Q2TVT7 (/IMP) Q2TVT7 (/IMP)
Embryonic eye morphogenesis GO:0048048 The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.	4	Q6VFT6 (/ISS) Q6VFT6 (/ISS) Q6VFT7 (/ISS) Q8MIP2 (/ISS)
Determination of ventral identity GO:0048264 The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.	4	Q91904 (/IMP) Q91904 (/IMP) Q91905 (/IMP) Q91905 (/IMP)
Cartilage development GO:0051216 The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.	4	Q5H7C2 (/IMP) Q7SY22 (/IMP) Q9DE24 (/IMP) Q9DE25 (/IMP)
Granulosa cell differentiation GO:0060014 The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals.	4	Q6VFT6 (/ISS) Q6VFT6 (/ISS) Q6VFT7 (/ISS) Q8MIP2 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122 Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.	3	O88470 (/IMP) O88470 (/IMP) Q61572 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122 Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.	3	Q12948 (/ISS) Q12948 (/ISS) Q99958 (/ISS)
Skeletal system development GO:0001501 The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).	3	Q61572 (/IMP) Q61850 (/IMP) Q61850 (/IMP)
Ossification GO:0001503 The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.	3	Q61572 (/IMP) Q61850 (/IMP) Q61850 (/IMP)
Ureteric bud development GO:0001657 The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.	3	Q61572 (/IMP) Q61850 (/IMP) Q61850 (/IMP)
Neural crest cell migration GO:0001755 The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.	3	Q6DG75 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Somitogenesis GO:0001756 The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Kidney development GO:0001822 The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.	3	Q61572 (/IMP) Q61850 (/IMP) Q61850 (/IMP)
Lymph vessel development GO:0001945 The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Lymphangiogenesis GO:0001946 Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.	3	Q61850 (/ISS) Q61850 (/ISS) Q6NVT7 (/ISS)
Blood vessel remodeling GO:0001974 The reorganization or renovation of existing blood vessels.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Heart morphogenesis GO:0003007 The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Transcription, DNA-templated GO:0006351 The cellular synthesis of RNA on a template of DNA.	3	Q32NP8 (/ISS) Q32NP8 (/ISS) Q68F77 (/ISS)
Regulation of transcription, DNA-templated GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.	3	Q9PVY8 (/NAS) Q9PVY9 (/NAS) Q9PVY9 (/NAS)
Cell adhesion GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.	3	Q32NP8 (/ISS) Q32NP8 (/ISS) Q68F77 (/ISS)
Notch signaling pathway GO:0007219 A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Brain development GO:0007420 The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).	3	Q5H7C2 (/IMP) Q61572 (/IMP) Q7SY22 (/IMP)
Heart development GO:0007507 The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Insulin receptor signaling pathway GO:0008286 The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	3	Q61850 (/ISS) Q61850 (/ISS) Q6NVT7 (/ISS)
Response to hormone GO:0009725 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.	3	Q61850 (/ISS) Q61850 (/ISS) Q6NVT7 (/ISS)
Epidermal cell differentiation GO:0009913 The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.	3	A3KNJ3 (/IMP) F1R746 (/IMP) Q7T1C1 (/IMP)
Neural crest cell development GO:0014032 The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Neural crest cell development GO:0014032 The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.	3	Q6DG75 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Water homeostasis GO:0030104 Any process involved in the maintenance of an internal steady state of water within an organism or cell.	3	A3KNJ3 (/IMP) F1R746 (/IMP) Q7T1C1 (/IMP)
Collagen fibril organization GO:0030199 Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.	3	Q61572 (/IMP) Q61850 (/IMP) Q61850 (/IMP)
Otic vesicle formation GO:0030916 The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear.	3	Q6DG75 (/IGI) Q7T2N8 (/IGI) Q804B2 (/IGI)
Otic vesicle formation GO:0030916 The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear.	3	Q6DG75 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Embryonic heart tube development GO:0035050 The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Otic placode formation GO:0043049 The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain.	3	Q6DG75 (/IGI) Q7T2N8 (/IGI) Q804B2 (/IGI)
Otic placode formation GO:0043049 The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain.	3	Q6DG75 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.	3	Q61572 (/ISO) Q61850 (/ISO) Q61850 (/ISO)
Regulation of organ growth GO:0046620 Any process that modulates the frequency, rate or extent of growth of an organ of an organism.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Vascular endothelial growth factor receptor signaling pathway GO:0048010 Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Paraxial mesoderm formation GO:0048341 The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Neuron development GO:0048666 The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.	3	Q6DG75 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Pronephros development GO:0048793 The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.	3	Q32NP8 (/ISS) Q32NP8 (/ISS) Q68F77 (/ISS)
Artery morphogenesis GO:0048844 The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.	3	Q61572 (/IMP) Q61850 (/IMP) Q61850 (/IMP)
Lateral line ganglion development GO:0048890 The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear.	3	Q6DG75 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Ventricular cardiac muscle tissue morphogenesis GO:0055010 The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Cardiac muscle cell proliferation GO:0060038 The expansion of a cardiac muscle cell population by cell division.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Ectodermal placode formation GO:0060788 The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.	3	Q6DG75 (/IGI) Q7T2N8 (/IGI) Q804B2 (/IGI)
Cranial ganglion development GO:0061550 The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.	3	Q6DG75 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Otic vesicle development GO:0071599 The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear.	3	Q6DG75 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Otic vesicle morphogenesis GO:0071600 The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear.	3	Q6DG75 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Ectodermal placode development GO:0071696 The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.	3	Q6DG75 (/IMP) Q7T2N8 (/IMP) Q804B2 (/IMP)
Negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.	3	Q61572 (/IGI) Q61850 (/IGI) Q61850 (/IGI)
Skeletal system development GO:0001501 The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).	2	Q61850 (/IGI) Q61850 (/IGI)
Ovarian follicle development GO:0001541 The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.	2	O88470 (/IGI) O88470 (/IGI)
Ovarian follicle development GO:0001541 The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.	2	O88470 (/ISO) O88470 (/ISO)
Oocyte growth GO:0001555 The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.	2	Q2TVT7 (/IMP) Q2TVT7 (/IMP)
Blood vessel development GO:0001568 The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.	2	Q61574 (/IMP) Q61574 (/IMP)
Branching involved in blood vessel morphogenesis GO:0001569 The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.	2	Q61850 (/IGI) Q61850 (/IGI)
Eye development GO:0001654 The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.	2	Q12948 (/IDA) Q12948 (/IDA)
Metanephros development GO:0001656 The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.	2	Q61850 (/IMP) Q61850 (/IMP)
Ureteric bud development GO:0001657 The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.	2	Q12948 (/ISS) Q12948 (/ISS)
Neural crest cell migration GO:0001755 The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.	2	Q9DE24 (/IGI) Q9DE25 (/IGI)
Kidney development GO:0001822 The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.	2	Q12948 (/ISS) Q12948 (/ISS)
Vasculature development GO:0001944 The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.	2	Q9DE24 (/IGI) Q9DE25 (/IGI)
Vasculature development GO:0001944 The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.	2	Q9DE24 (/IMP) Q9DE25 (/IMP)
Lymphangiogenesis GO:0001946 Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.	2	Q61850 (/ISO) Q61850 (/ISO)
Endochondral ossification GO:0001958 Replacement ossification wherein bone tissue replaces cartilage.	2	Q12948 (/ISS) Q12948 (/ISS)
Extraocular skeletal muscle development GO:0002074 The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.	2	P58012 (/IMP) P58012 (/IMP)
Extraocular skeletal muscle development GO:0002074 The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.	2	O88470 (/ISO) O88470 (/ISO)
Apoptotic DNA fragmentation GO:0006309 The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.	2	P58012 (/IMP) P58012 (/IMP)
Apoptotic DNA fragmentation GO:0006309 The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.	2	O88470 (/ISO) O88470 (/ISO)
Transcription, DNA-templated GO:0006351 The cellular synthesis of RNA on a template of DNA.	2	Q9PVZ3 (/IMP) Q9PVZ3 (/IMP)
Regulation of transcription, DNA-templated GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.	2	Q9PVZ3 (/IMP) Q9PVZ3 (/IMP)
Regulation of transcription, DNA-templated GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.	2	Q63246 (/TAS) Q64731 (/TAS)
Cell adhesion GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.	2	Q9PVZ3 (/IMP) Q9PVZ3 (/IMP)
Single fertilization GO:0007338 The union of male and female gametes to form a zygote.	2	O88470 (/IGI) O88470 (/IGI)
Specification of segmental identity, head GO:0007380 The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.	2	P32027 (/IMP) P32027 (/IMP)
Mesoderm development GO:0007498 The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.	2	Q9PVY9 (/IEP) Q9PVY9 (/IEP)
Mesoderm development GO:0007498 The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.	2	Q9PVZ3 (/IMP) Q9PVZ3 (/IMP)
Heart development GO:0007507 The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.	2	Q12948 (/IDA) Q12948 (/IDA)
Cell population proliferation GO:0008283 The multiplication or reproduction of cells, resulting in the expansion of a cell population.	2	Q12948 (/IDA) Q12948 (/IDA)
Insulin receptor signaling pathway GO:0008286 The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	2	Q61850 (/ISO) Q61850 (/ISO)
Female gonad development GO:0008585 The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.	2	O88470 (/IGI) O88470 (/IGI)
Response to hormone GO:0009725 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.	2	Q61850 (/ISO) Q61850 (/ISO)
Embryo development ending in birth or egg hatching GO:0009792 The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.	2	Q12951 (/NAS) Q12951 (/NAS)
Positive regulation of endothelial cell migration GO:0010595 Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.	2	Q61850 (/IDA) Q61850 (/IDA)
Positive regulation of gene expression GO:0010628 Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.	2	Q02360 (/IMP) Q02360 (/IMP)
Positive regulation of epithelial to mesenchymal transition GO:0010718 Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.	2	Q12948 (/IMP) Q12948 (/IMP)
Mesenchymal cell development GO:0014031 The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.	2	Q12948 (/ISS) Q12948 (/ISS)
Cell migration GO:0016477 The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.	2	Q12948 (/IDA) Q12948 (/IDA)
Cell migration GO:0016477 The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.	2	Q12948 (/IMP) Q12948 (/IMP)
Negative regulation of angiogenesis GO:0016525 Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.	2	Q12948 (/ISS) Q12948 (/ISS)
Female somatic sex determination GO:0019101 The determination of sex and sexual phenotypes in a female organism's soma.	2	O88470 (/IMP) O88470 (/IMP)
Cerebellum development GO:0021549 The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.	2	Q12948 (/ISS) Q12948 (/ISS)
Cell differentiation GO:0030154 The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.	2	P58012 (/NAS) P58012 (/NAS)
Positive regulation of integrin activation GO:0033625 Any process that activates or increases the frequency, rate, or extent of integrin activation.	2	Q61850 (/IC) Q61850 (/IC)
Positive regulation of cell adhesion mediated by integrin GO:0033630 Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.	2	Q61850 (/IDA) Q61850 (/IDA)
Positive regulation of luteinizing hormone secretion GO:0033686 Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone.	2	O88470 (/IGI) O88470 (/IGI)
Pectoral fin morphogenesis GO:0035138 The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.	2	Q5H7C2 (/IMP) Q7SY22 (/IMP)
Positive regulation of vascular wound healing GO:0035470 Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.	2	Q61850 (/IDA) Q61850 (/IDA)
Maintenance of lens transparency GO:0036438 A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina.	2	Q12948 (/ISS) Q12948 (/ISS)
Vascular endothelial growth factor signaling pathway GO:0038084 A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.	2	Q12948 (/ISS) Q12948 (/ISS)
Positive regulation of multicellular organism growth GO:0040018 Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.	2	Q61574 (/IMP) Q61574 (/IMP)
Odontogenesis of dentin-containing tooth GO:0042475 The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.	2	Q12948 (/IMP) Q12948 (/IMP)
Negative regulation of endodermal cell fate specification GO:0042664 Any process that restricts, stops or prevents a cell from specifying into an endoderm cell.	2	Q7ZYQ0 (/IMP) Q7ZYQ0 (/IMP)
Positive regulation of apoptotic process GO:0043065 Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.	2	P58012 (/IGI) P58012 (/IGI)
Positive regulation of apoptotic process GO:0043065 Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.	2	P58012 (/IMP) P58012 (/IMP)
Positive regulation of apoptotic process GO:0043065 Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.	2	O88470 (/ISO) O88470 (/ISO)
Regulation of vascular permeability GO:0043114 Any process that modulates the extent to which blood vessels can be pervaded by fluid.	2	Q9DE24 (/IGI) Q9DE25 (/IGI)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.	2	P58012 (/IMP) P58012 (/IMP)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.	2	O88470 (/ISO) O88470 (/ISO)
Positive regulation of DNA binding GO:0043388 Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).	2	Q12948 (/IMP) Q12948 (/IMP)
Negative regulation of DNA-binding transcription factor activity GO:0043433 Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.	2	Q61574 (/IDA) Q61574 (/IDA)
Positive regulation of keratinocyte differentiation GO:0045618 Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.	2	Q12948 (/IMP) Q12948 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.	2	O88470 (/IMP) O88470 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.	2	O88470 (/ISO) O88470 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.	2	Q12948 (/NAS) Q12948 (/NAS)
Negative regulation of mitotic cell cycle GO:0045930 Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.	2	Q12948 (/IDA) Q12948 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	2	O88470 (/IGI) O88470 (/IGI)
Positive regulation of follicle-stimulating hormone secretion GO:0046881 Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone.	2	O88470 (/IGI) O88470 (/IGI)
Negative regulation of mesodermal cell fate determination GO:0048335 Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate determination.	2	Q7ZYQ0 (/IMP) Q7ZYQ0 (/IMP)
Paraxial mesodermal cell fate commitment GO:0048343 The process in which a cell becomes committed to become a paraxial mesoderm cell.	2	Q61850 (/IMP) Q61850 (/IMP)
Maintenance of animal organ identity GO:0048496 The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized.	2	F1QJW8 (/IGI) Q1JPV2 (/IGI)
Maintenance of animal organ identity GO:0048496 The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized.	2	F1QJW8 (/IMP) Q1JPV2 (/IMP)
Embryonic cranial skeleton morphogenesis GO:0048701 The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase.	2	Q61850 (/IMP) Q61850 (/IMP)
Embryonic skeletal system morphogenesis GO:0048704 The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.	2	Q61850 (/IMP) Q61850 (/IMP)
Pronephros development GO:0048793 The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.	2	Q9PVZ3 (/IEP) Q9PVZ3 (/IEP)
Neuromuscular process controlling balance GO:0050885 Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.	2	Q61574 (/IMP) Q61574 (/IMP)
Granulosa cell differentiation GO:0060014 The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals.	2	O88470 (/IMP) O88470 (/IMP)
Uterus development GO:0060065 The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure.	2	O88470 (/IGI) O88470 (/IGI)
Cerebellum vasculature development GO:0061300 The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure.	2	Q9DE24 (/IGI) Q9DE25 (/IGI)
Cellular response to epidermal growth factor stimulus GO:0071364 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.	2	Q12948 (/IMP) Q12948 (/IMP)
Glomerular epithelium development GO:0072010 The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells in the metanephros.	2	Q12948 (/ISS) Q12948 (/ISS)
Glomerular endothelium development GO:0072011 The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus.	2	Q61850 (/IMP) Q61850 (/IMP)
Glomerular visceral epithelial cell differentiation GO:0072112 The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.	2	Q61850 (/IMP) Q61850 (/IMP)
Glomerular mesangial cell development GO:0072144 The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure.	2	Q61850 (/IMP) Q61850 (/IMP)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.	2	Q61850 (/IDA) Q61850 (/IDA)
Negative regulation of cold-induced thermogenesis GO:0120163 Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.	2	Q61850 (/ISO) Q61850 (/ISO)
Negative regulation of lymphangiogenesis GO:1901491 Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis.	2	Q12948 (/ISS) Q12948 (/ISS)
Positive regulation of hematopoietic progenitor cell differentiation GO:1901534 Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.	2	Q12948 (/ISS) Q12948 (/ISS)
Positive regulation of hematopoietic stem cell differentiation GO:1902038 Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation.	2	Q12948 (/ISS) Q12948 (/ISS)
Positive regulation of core promoter binding GO:1904798 Any process that activates or increases the frequency, rate or extent of core promoter binding.	2	Q12948 (/ISS) Q12948 (/ISS)
Regulation of platelet-derived growth factor receptor-alpha signaling pathway GO:2000583 Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway.	2	Q9DE24 (/IGI) Q9DE25 (/IGI)
Ovarian follicle development GO:0001541 The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.	1	Q8MIP2 (/IEP)
Blood vessel development GO:0001568 The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.	1	O43638 (/ISS)
Eye development GO:0001654 The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.	1	Q61572 (/IMP)
Eye development GO:0001654 The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.	1	Q61572 (/ISO)
In utero embryonic development GO:0001701 The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.	1	Q61572 (/IMP)
Somitogenesis GO:0001756 The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.	1	Q9DE25 (/IMP)
Lymphangiogenesis GO:0001946 Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.	1	Q99958 (/IMP)
Endochondral ossification GO:0001958 Replacement ossification wherein bone tissue replaces cartilage.	1	Q61572 (/IMP)
Regulation of transcription, DNA-templated GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.	1	Q61572 (/ISO)
Multicellular organism development GO:0007275 The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).	1	Q12952 (/NAS)
Ectoderm development GO:0007398 The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.	1	Q6P2Z3 (/ISS)
Visceral mesoderm-endoderm interaction involved in midgut development GO:0007495 The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut.	1	Q64731 (/IMP)
Visceral mesoderm-endoderm interaction involved in midgut development GO:0007495 The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut.	1	Q12952 (/ISS)
Mesoderm development GO:0007498 The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.	1	Q99958 (/NAS)
Motor neuron axon guidance GO:0008045 The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.	1	Q9DE25 (/IMP)
Estrogen metabolic process GO:0008210 The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.	1	Q8MIP2 (/NAS)
Cell population proliferation GO:0008283 The multiplication or reproduction of cells, resulting in the expansion of a cell population.	1	Q61572 (/ISO)
Cell population proliferation GO:0008283 The multiplication or reproduction of cells, resulting in the expansion of a cell population.	1	Q61572 (/ISS)
Insulin receptor signaling pathway GO:0008286 The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	1	Q99958 (/IDA)
Germ cell migration GO:0008354 The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.	1	Q61572 (/IMP)
Response to hormone GO:0009725 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.	1	Q99958 (/IDA)
Positive regulation of endothelial cell migration GO:0010595 Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.	1	Q99958 (/ISS)
Positive regulation of gene expression GO:0010628 Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.	1	Q61572 (/IDA)
Positive regulation of epithelial to mesenchymal transition GO:0010718 Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.	1	Q61572 (/ISO)
Positive regulation of epithelial to mesenchymal transition GO:0010718 Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.	1	Q61572 (/ISS)
Mesenchymal cell development GO:0014031 The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.	1	Q61572 (/IDA)
Cell migration GO:0016477 The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.	1	Q61572 (/ISO)
Cell migration GO:0016477 The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.	1	Q61572 (/ISS)
Negative regulation of angiogenesis GO:0016525 Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.	1	Q61572 (/IMP)
Cerebellum development GO:0021549 The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.	1	Q61572 (/IMP)
Regulation of Wnt signaling pathway GO:0030111 Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.	1	Q64731 (/IMP)
Regulation of Wnt signaling pathway GO:0030111 Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.	1	Q12952 (/ISS)
Proteoglycan biosynthetic process GO:0030166 The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.	1	Q64731 (/IMP)
Proteoglycan biosynthetic process GO:0030166 The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.	1	Q12952 (/ISS)
Glycosaminoglycan metabolic process GO:0030203 The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.	1	Q61572 (/IMP)
Adrenal gland development GO:0030325 The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.	1	Q9DE25 (/IGI)
Lacrimal gland development GO:0032808 The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye.	1	Q61572 (/IMP)
Pectoral fin development GO:0033339 The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure.	1	Q9DE25 (/IMP)
Positive regulation of cell adhesion mediated by integrin GO:0033630 Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.	1	Q99958 (/ISS)
Positive regulation of vascular wound healing GO:0035470 Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.	1	Q99958 (/ISS)
Maintenance of lens transparency GO:0036438 A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina.	1	Q61572 (/IMP)
Vascular endothelial growth factor signaling pathway GO:0038084 A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.	1	Q61572 (/IMP)
Pronephric glomerulus development GO:0039021 The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.	1	Q9DE25 (/IGI)
Regulation of fibroblast growth factor receptor signaling pathway GO:0040036 Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.	1	Q9DE25 (/IMP)
Inner ear morphogenesis GO:0042472 The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.	1	Q922I5 (/IMP)
Odontogenesis of dentin-containing tooth GO:0042475 The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.	1	Q61572 (/ISO)
Odontogenesis of dentin-containing tooth GO:0042475 The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.	1	Q61572 (/ISS)
Negative regulation of endodermal cell fate specification GO:0042664 Any process that restricts, stops or prevents a cell from specifying into an endoderm cell.	1	Q6P8A3 (/ISS)
Positive regulation of DNA binding GO:0043388 Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).	1	Q61572 (/ISO)
Positive regulation of DNA binding GO:0043388 Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).	1	Q61572 (/ISS)
Negative regulation of DNA-binding transcription factor activity GO:0043433 Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.	1	O43638 (/ISS)
Positive regulation of keratinocyte differentiation GO:0045618 Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.	1	Q61572 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.	1	O43638 (/ISS)
Negative regulation of mitotic cell cycle GO:0045930 Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.	1	Q61572 (/ISO)
Negative regulation of mitotic cell cycle GO:0045930 Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.	1	Q61572 (/ISS)
Determination of ventral identity GO:0048264 The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.	1	Q6P2Z3 (/ISS)
Negative regulation of mesodermal cell fate determination GO:0048335 Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate determination.	1	Q6P8A3 (/ISS)
Paraxial mesoderm formation GO:0048341 The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.	1	Q61572 (/IMP)
Negative regulation of retinoic acid receptor signaling pathway GO:0048387 Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity.	1	Q9DE25 (/IMP)
Mesenchymal cell differentiation GO:0048762 The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.	1	Q61572 (/IMP)
Peyer's patch morphogenesis GO:0061146 The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes.	1	Q64731 (/IMP)
Closure of optic fissure GO:0061386 The closure of the temporary ventral gap in the optic cup that contributes to its shaping.	1	Q9DE25 (/IMP)
Chemokine-mediated signaling pathway GO:0070098 A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.	1	Q61572 (/IMP)
Cellular response to epidermal growth factor stimulus GO:0071364 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.	1	Q61572 (/ISO)
Cellular response to epidermal growth factor stimulus GO:0071364 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.	1	Q61572 (/ISS)
Glomerular epithelium development GO:0072010 The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells in the metanephros.	1	Q61572 (/IMP)
Glomerular visceral epithelial cell development GO:0072015 The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.	1	Q9DE25 (/IGI)
Glomerular visceral epithelial cell development GO:0072015 The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.	1	Q9DE25 (/IMP)
Glomerular visceral epithelial cell fate commitment GO:0072149 The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.	1	Q9DE25 (/IGI)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.	1	Q99958 (/ISS)
Negative regulation of cold-induced thermogenesis GO:0120163 Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.	1	Q99958 (/IMP)
Negative regulation of lymphangiogenesis GO:1901491 Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis.	1	Q61572 (/IMP)
Positive regulation of hematopoietic progenitor cell differentiation GO:1901534 Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.	1	Q61572 (/IMP)
Positive regulation of hematopoietic stem cell differentiation GO:1902038 Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation.	1	Q61572 (/IMP)
Regulation of Notch signaling pathway involved in somitogenesis GO:1902366 Any process that modulates the frequency, rate or extent of Notch signaling pathway involved in somitogenesis.	1	Q9DE25 (/IMP)
Positive regulation of core promoter binding GO:1904798 Any process that activates or increases the frequency, rate or extent of core promoter binding.	1	Q61572 (/IMP)
Cellular response to chemokine GO:1990869 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.	1	Q61572 (/IMP)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	30	O43638 (/ISS) O88470 (/ISS) O88470 (/ISS) Q28D67 (/ISS) Q28HT3 (/ISS) Q32NP8 (/ISS) Q32NP8 (/ISS) Q3I5G5 (/ISS) Q4VUF1 (/ISS) Q5J7N5 (/ISS) (20 more)
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	18	O88470 (/IDA) O88470 (/IDA) P32027 (/IDA) P32027 (/IDA) P58012 (/IDA) P58012 (/IDA) Q02360 (/IDA) Q02360 (/IDA) Q12948 (/IDA) Q12948 (/IDA) (8 more)
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	10	Q12948 (/IC) Q12948 (/IC) Q12951 (/IC) Q12951 (/IC) Q12952 (/IC) Q5H7C2 (/IC) Q61850 (/IC) Q61850 (/IC) Q7SY22 (/IC) Q922I5 (/IC)
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	5	O88470 (/ISO) O88470 (/ISO) Q61572 (/ISO) Q61850 (/ISO) Q61850 (/ISO)
Nucleoplasm GO:0005654 That part of the nuclear content other than the chromosomes or the nucleolus.	5	Q12948 (/IDA) Q12948 (/IDA) Q99958 (/IDA) W6CJ52 (/IDA) W6CJ52 (/IDA)
Nucleolus GO:0005730 A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.	4	E0XEN6 (/IDA) E0XEN6 (/IDA) Q12951 (/IDA) Q12951 (/IDA)
Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	4	Q12948 (/IDA) Q12948 (/IDA) W6CJ52 (/IDA) W6CJ52 (/IDA)
Intracellular membrane-bounded organelle GO:0043231 Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.	4	E0XEN6 (/IDA) E0XEN6 (/IDA) Q12951 (/IDA) Q12951 (/IDA)
Intercellular bridge GO:0045171 A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.	4	P58012 (/IDA) P58012 (/IDA) Q53ZD3 (/IDA) Q53ZD3 (/IDA)
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	3	Q9PVY8 (/NAS) Q9PVY9 (/NAS) Q9PVY9 (/NAS)
Nucleoplasm GO:0005654 That part of the nuclear content other than the chromosomes or the nucleolus.	3	Q61572 (/ISO) Q61850 (/ISO) Q61850 (/ISO)
Nucleoplasm GO:0005654 That part of the nuclear content other than the chromosomes or the nucleolus.	2	P58012 (/TAS) P58012 (/TAS)
Nuclear heterochromatin GO:0005720 A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.	2	Q12948 (/IDA) Q12948 (/IDA)
Nuclear body GO:0016604 Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.	2	Q61850 (/ISO) Q61850 (/ISO)
Intercellular bridge GO:0045171 A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.	2	O88470 (/ISO) O88470 (/ISO)
Cell GO:0005623 The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.	1	L7WG50 (/IDA)
Nuclear heterochromatin GO:0005720 A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.	1	Q61572 (/ISO)
Nuclear heterochromatin GO:0005720 A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.	1	Q61572 (/ISS)
Nucleolus GO:0005730 A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.	1	Q922I5 (/ISO)
Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	1	Q61572 (/ISO)
Nuclear body GO:0016604 Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.	1	Q99958 (/IDA)
Intracellular membrane-bounded organelle GO:0043231 Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.	1	Q922I5 (/ISO)

CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Functional Families

FunFam 16: Forkhead box protein I1

There are 56 GO terms relating to "molecular function"

There are 251 GO terms relating to "biological process"

There are 22 GO terms relating to "cellular component"