The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 103: Two-component system response regulator NarL

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
148 P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA)
(138 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
148 P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI)
(138 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
148 P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA)
(138 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
148 P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI)
(138 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
148 P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP)
(138 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
148 P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI)
(138 more)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
148 P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP)
(138 more)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
148 P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP)
(138 more)
Regulation of nitrate assimilation GO:0090352
Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances.
148 P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP) P0AF28 (/IMP)
(138 more)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
148 P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA)
(138 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
148 P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA) P0AF28 (/IDA)
(138 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
148 P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI) P0AF28 (/IPI)
(138 more)
CATH-Gene3D is a Global Biodata Core Resource Learn more...