The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Forkhead box P2 isoform B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 50 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
23 P58463 (/ISS) Q2LEZ0 (/ISS) Q4VYR7 (/ISS) Q4VYS1 (/ISS) Q5QL03 (/ISS) Q5W1J5 (/ISS) Q6BBQ1 (/ISS) Q6QBA5 (/ISS) Q6S511 (/ISS) Q6U8D7 (/ISS)
(13 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
19 P58463 (/ISS) Q4VYR7 (/ISS) Q4VYS1 (/ISS) Q5QL03 (/ISS) Q5W1J5 (/ISS) Q6QBA5 (/ISS) Q6S511 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q8HZ00 (/ISS)
(9 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
19 O15409 (/IPI) P58462 (/IPI) P58463 (/IPI) Q5W1J5 (/IPI) Q8IVH2 (/IPI) Q99JB6 (/IPI) Q99JB6 (/IPI) Q9BZS1 (/IPI) Q9H334 (/IPI) Q9H334 (/IPI)
(9 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
14 O15409 (/ISA) Q8IVH2 (/ISA) Q9BZS1 (/ISA) Q9H334 (/ISA) Q9H334 (/ISA) Q9H334 (/ISA) Q9H334 (/ISA) Q9H334 (/ISA) Q9H334 (/ISA) Q9H334 (/ISA)
(4 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
14 O15409 (/ISM) Q8IVH2 (/ISM) Q9BZS1 (/ISM) Q9H334 (/ISM) Q9H334 (/ISM) Q9H334 (/ISM) Q9H334 (/ISM) Q9H334 (/ISM) Q9H334 (/ISM) Q9H334 (/ISM)
(4 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
12 O15409 (/NAS) Q9H334 (/NAS) Q9H334 (/NAS) Q9H334 (/NAS) Q9H334 (/NAS) Q9H334 (/NAS) Q9H334 (/NAS) Q9H334 (/NAS) Q9H334 (/NAS) Q9H334 (/NAS)
(2 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
12 O15409 (/IPI) Q9H334 (/IPI) Q9H334 (/IPI) Q9H334 (/IPI) Q9H334 (/IPI) Q9H334 (/IPI) Q9H334 (/IPI) Q9H334 (/IPI) Q9H334 (/IPI) Q9H334 (/IPI)
(2 more)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
11 Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP)
(1 more)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
6 O15409 (/IDA) P58462 (/IDA) P58463 (/IDA) Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
NFAT protein binding GO:0051525
Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 A0A0B4K6N2 (/IDA) O15409 (/IDA) Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
4 O15409 (/IDA) P58462 (/IDA) P58463 (/IDA) Q9DBY0 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 P58462 (/IPI) P58463 (/IPI) Q9BZS1 (/IPI) Q9DBY0 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
4 O15409 (/IDA) Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
3 P58462 (/IMP) P58463 (/IMP) Q9DBY0 (/IMP)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
3 Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q9BZS1 (/ISS)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 P58462 (/IDA) Q99JB6 (/IDA) Q99JB6 (/IDA)
Core promoter sequence-specific DNA binding GO:0001046
Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
3 K4EPC4 (/IDA) Q6QBA5 (/IDA) Q6TKS2 (/IDA)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
3 A4IFD2 (/ISS) P58462 (/ISS) Q498D1 (/ISS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 P58462 (/IPI) P58463 (/IPI) Q9DBY0 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 Q4VYR7 (/ISS) Q4VYS1 (/ISS) Q5W1J5 (/ISS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 P58463 (/IMP) Q9DBY0 (/IMP)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
NFAT protein binding GO:0051525
Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P58462 (/IGI)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P58462 (/IC)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q9DBY0 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q9BZS1 (/IMP)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 P58462 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q9BZS1 (/NAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P58462 (/TAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q498D1 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 P58462 (/ISO)
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
1 Q9BZS1 (/IPI)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
1 Q9BZS1 (/IPI)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 Q498D1 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 P58462 (/ISO)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 P0CF24 (/IPI)
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
1 Q9BZS1 (/NAS)
NFAT protein binding GO:0051525
Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
1 Q9BZS1 (/IPI)

There are 223 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
17 O15409 (/IDA) P58462 (/IDA) P58463 (/IDA) Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(7 more)
Caudate nucleus development GO:0021757
The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain.
15 P58463 (/ISS) Q4VYS1 (/ISS) Q5QL03 (/ISS) Q6QBA5 (/ISS) Q6S511 (/ISS) Q8HZ00 (/ISS) Q8HZ00 (/ISS) Q8HZ00 (/ISS) Q8MJ97 (/ISS) Q8MJ98 (/ISS)
(5 more)
Putamen development GO:0021758
The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain.
15 P58463 (/ISS) Q4VYS1 (/ISS) Q5QL03 (/ISS) Q6QBA5 (/ISS) Q6S511 (/ISS) Q8HZ00 (/ISS) Q8HZ00 (/ISS) Q8HZ00 (/ISS) Q8MJ97 (/ISS) Q8MJ98 (/ISS)
(5 more)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
13 Q99JB6 (/IDA) Q99JB6 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(3 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
12 Q9BZS1 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP)
(2 more)
Negative regulation of B cell apoptotic process GO:0002903
Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
11 Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP)
(1 more)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
11 Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP)
(1 more)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Regulation of tumor necrosis factor production GO:0032680
Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
11 Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS)
(1 more)
Chemokine (C-C motif) ligand 2 secretion GO:0035926
The regulated release of chemokine (C-C motif) ligand 2 (CCL2) from a cell.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Osteoclast development GO:0036035
The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Macrophage activation GO:0042116
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Monocyte activation GO:0042117
The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Endothelial cell activation GO:0042118
The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
11 Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP)
(1 more)
Regulation of monocyte differentiation GO:0045655
Any process that modulates the frequency, rate or extent of monocyte differentiation.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
11 A4IFD2 (/ISS) Q2LEZ0 (/ISS) Q498D1 (/ISS) Q4VYR7 (/ISS) Q4VYS1 (/ISS) Q5W1J5 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS)
(1 more)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
11 Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP)
(1 more)
Regulation of interleukin-1 beta secretion GO:0050706
Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Positive regulation of B cell receptor signaling pathway GO:0050861
Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
11 Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP)
(1 more)
Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
T follicular helper cell differentiation GO:0061470
The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell.
11 Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS)
(1 more)
Interleukin-21 secretion GO:0072619
The regulated release of interleukin-21 from a cell.
11 Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS) Q9H334 (/ISS)
(1 more)
Regulation of defense response to bacterium GO:1900424
Any process that modulates the frequency, rate or extent of defense response to bacterium.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Regulation of macrophage colony-stimulating factor production GO:1901256
Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor production.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Regulation of endothelial tube morphogenesis GO:1901509
Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis.
11 Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP) Q9H334 (/IMP)
(1 more)
Regulation of interleukin-12 secretion GO:2001182
Any process that modulates the frequency, rate or extent of interleukin-12 secretion.
11 Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(1 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
8 Q2LEZ0 (/ISS) Q58NQ4 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS) Q9BZS1 (/ISS)
Negative regulation of T cell cytokine production GO:0002725
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of interleukin-4 production GO:0032713
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of CREB transcription factor activity GO:0032792
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of cytokine biosynthetic process GO:0042036
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of interleukin-2 biosynthetic process GO:0045085
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of immune response GO:0050777
Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
6 Q2LEZ0 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
5 P58462 (/IDA) P58463 (/IDA) Q99JB6 (/IDA) Q99JB6 (/IDA) Q9DBY0 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
5 P58463 (/IMP) Q498D1 (/IMP) Q99JB6 (/IMP) Q99JB6 (/IMP) Q9DBY0 (/IMP)
Vocal learning GO:0042297
A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others.
4 K4EPC4 (/IMP) P58463 (/IMP) Q6QBA5 (/IMP) Q6TKS2 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 P58462 (/IMP) Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 P58462 (/IMP) Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP)
Negative regulation of T-helper 17 cell differentiation GO:2000320
Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.
4 Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS) Q99JB6 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 Q4VYR7 (/ISS) Q4VYS1 (/ISS) Q5W1J5 (/ISS)
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment GO:0002362
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
3 Q99JB6 (/TAS) Q99JB6 (/TAS) Q9BZS1 (/TAS)
Regulation of T cell anergy GO:0002667
Any process that modulates the frequency, rate, or extent of T cell anergy.
3 Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q9BZS1 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 K4EPC4 (/IMP) Q6QBA5 (/IMP) Q6TKS2 (/IMP)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
3 Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
3 Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP)
Negative regulation of interleukin-17 production GO:0032700
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
3 Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
3 Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
3 Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP)
Negative regulation of interleukin-4 production GO:0032713
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.
3 Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA)
Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0032831
Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.
3 Q99JB6 (/TAS) Q99JB6 (/TAS) Q9BZS1 (/TAS)
Regulation of T cell proliferation GO:0042129
Any process that modulates the frequency, rate or extent of T cell proliferation.
3 A8WFW7 (/IMP) C3W4Z9 (/IMP) D2EAB6 (/IMP)
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
3 Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA)
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
3 Q99JB6 (/IMP) Q99JB6 (/IMP) Q9BZS1 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA)
Regulation of synaptic transmission, glutamatergic GO:0051966
Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
3 K4EPC4 (/IMP) Q6QBA5 (/IMP) Q6TKS2 (/IMP)
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
3 K4EPC4 (/IMP) Q6QBA5 (/IMP) Q6TKS2 (/IMP)
Learned vocalization behavior GO:0098583
A vocalization behavior that is the result of learning.
3 K4EPC4 (/IMP) Q6QBA5 (/IMP) Q6TKS2 (/IMP)
B cell homeostasis GO:0001782
The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 Q99JB6 (/IGI) Q99JB6 (/IGI)
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Positive regulation of mesenchymal cell proliferation GO:0002053
The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
2 P58462 (/IGI) P58463 (/IGI)
Myeloid cell homeostasis GO:0002262
The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0002361
The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
T cell mediated immunity GO:0002456
Any process involved in the carrying out of an immune response by a T cell.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Tolerance induction GO:0002507
A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Tolerance induction to self antigen GO:0002513
Tolerance induction directed at self antigens.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Regulation of immunoglobulin production GO:0002637
Any process that modulates the frequency, rate, or extent of immunoglobulin production.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Positive regulation of T cell tolerance induction GO:0002666
Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Regulation of T cell anergy GO:0002667
Any process that modulates the frequency, rate, or extent of T cell anergy.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Positive regulation of T cell anergy GO:0002669
Any process that activates or increases the frequency, rate, or extent of T cell anergy.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Negative regulation of chronic inflammatory response GO:0002677
Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Negative regulation of chronic inflammatory response GO:0002677
Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Negative regulation of T cell cytokine production GO:0002725
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Positive regulation of peripheral T cell tolerance induction GO:0002851
Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q99JB6 (/IGI) Q99JB6 (/IGI)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 P58462 (/IMP) Q9DBY0 (/IMP)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
2 P58462 (/IGI) P58463 (/IGI)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Ventral spinal cord development GO:0021517
The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.
2 P58462 (/IEP) Q58NQ4 (/IEP)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
2 P58462 (/IGI) P58463 (/IGI)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
2 P0CF24 (/IEP) Q498D1 (/IEP)
Negative regulation of histone deacetylation GO:0031064
Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of interleukin-17 production GO:0032700
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of interleukin-4 production GO:0032713
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Negative regulation of interleukin-4 production GO:0032713
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of interleukin-5 production GO:0032714
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Negative regulation of interleukin-5 production GO:0032714
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Negative regulation of CREB transcription factor activity GO:0032792
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0032831
Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Positive regulation of transforming growth factor beta1 production GO:0032914
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Positive regulation of immature T cell proliferation in thymus GO:0033092
Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
2 P0CF24 (/IEP) Q498D1 (/IEP)
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of histone acetylation GO:0035067
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Operant conditioning GO:0035106
Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior.
2 A0A0B4K6N2 (/IMP) Q9VH87 (/IMP)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
2 A0A0B4K6N2 (/IMP) Q9VH87 (/IMP)
Negative regulation of cytokine biosynthetic process GO:0042036
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of interferon-gamma biosynthetic process GO:0045077
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Negative regulation of interleukin-2 biosynthetic process GO:0045085
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Negative regulation of interleukin-2 biosynthetic process GO:0045085
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Male courtship behavior, veined wing generated song production GO:0045433
The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.
2 A0A0B4K6N2 (/IMP) Q9VH87 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
2 H0WFE7 (/IDA) Q4JNX5 (/IDA)
Positive regulation of regulatory T cell differentiation GO:0045591
Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Positive regulation of regulatory T cell differentiation GO:0045591
Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q99JB6 (/IDA) Q99JB6 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of isotype switching to IgE isotypes GO:0048294
Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Regulation of isotype switching to IgG isotypes GO:0048302
Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Smooth muscle tissue development GO:0048745
The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure.
2 P58462 (/IGI) P58463 (/IGI)
Negative regulation of lymphocyte proliferation GO:0050672
Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
2 P58462 (/IGI) P58463 (/IGI)
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Negative regulation of immune response GO:0050777
Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
2 Q99JB6 (/IMP) Q99JB6 (/IMP)
Lung secretory cell differentiation GO:0061140
The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part.
2 P58462 (/IGI) Q9DBY0 (/IGI)
Innate vocalization behavior GO:0098582
A vocalisation behavior that is innate, i.e. that does not need to be learned in order to occur.
2 P0CF24 (/IMP) P58462 (/IMP)
Regulation of lung goblet cell differentiation GO:1901249
Any process that modulates the frequency, rate or extent of lung goblet cell differentiation.
2 P58462 (/IGI) Q9DBY0 (/IGI)
Negative regulation of lung goblet cell differentiation GO:1901250
Any process that stops, prevents or reduces the frequency, rate or extent of lung goblet cell differentiation.
2 P58462 (/IGI) Q9DBY0 (/IGI)
Negative regulation of T-helper 17 cell differentiation GO:2000320
Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P58462 (/IGI)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P58462 (/ISO)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 P58462 (/IMP)
Pre-B cell differentiation GO:0002329
The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.
1 P58462 (/IMP)
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0002361
The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
1 B7ZLG1 (/IMP)
Positive regulation of immunoglobulin production GO:0002639
Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
1 P58462 (/IMP)
Negative regulation of T cell cytokine production GO:0002725
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
1 Q9BZS1 (/IDA)
Negative regulation of T cell cytokine production GO:0002725
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
1 Q9BZS1 (/IMP)
Negative regulation of B cell apoptotic process GO:0002903
Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.
1 P58462 (/ISS)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 Q9BZS1 (/NAS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9BZS1 (/NAS)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 P58462 (/IMP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 Q58NQ4 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9BZS1 (/IDA)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q9BZS1 (/IEP)
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
1 P58463 (/IMP)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 P58462 (/ISS)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 P58463 (/IMP)
Striatum development GO:0021756
The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.
1 Q498D1 (/IEP)
Caudate nucleus development GO:0021757
The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain.
1 O15409 (/IMP)
Putamen development GO:0021758
The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain.
1 O15409 (/IMP)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
1 O15409 (/IEP)
Regulation of Wnt signaling pathway GO:0030111
Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.
1 Q9BZS1 (/TAS)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
1 P58462 (/ISS)
Negative regulation of histone deacetylation GO:0031064
Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.
1 Q9BZS1 (/IGI)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 Q9BZS1 (/IDA)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P58462 (/ISS)
Regulation of tumor necrosis factor production GO:0032680
Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.
1 P58462 (/ISS)
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
1 Q9BZS1 (/IDA)
Negative regulation of CREB transcription factor activity GO:0032792
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.
1 Q9BZS1 (/IDA)
Immunoglobulin V(D)J recombination GO:0033152
The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined.
1 P58462 (/IMP)
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
1 Q9BZS1 (/IMP)
Chemokine (C-C motif) ligand 2 secretion GO:0035926
The regulated release of chemokine (C-C motif) ligand 2 (CCL2) from a cell.
1 P58462 (/ISS)
Osteoclast development GO:0036035
The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
1 P58462 (/ISS)
Negative regulation of cytokine biosynthetic process GO:0042036
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.
1 Q9BZS1 (/IDA)
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
1 Q9BZS1 (/IDA)
Macrophage activation GO:0042116
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 P58462 (/ISS)
Monocyte activation GO:0042117
The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 P58462 (/ISS)
Endothelial cell activation GO:0042118
The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 P58462 (/ISS)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
1 P58463 (/IMP)
T cell homeostasis GO:0043029
The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
1 Q9BZS1 (/NAS)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q9BZS1 (/IDA)
Negative regulation of interleukin-2 biosynthetic process GO:0045085
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
1 Q9BZS1 (/IMP)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 P58462 (/IGI)
Regulation of regulatory T cell differentiation GO:0045589
Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
1 Q9BZS1 (/TAS)
Regulation of monocyte differentiation GO:0045655
Any process that modulates the frequency, rate or extent of monocyte differentiation.
1 P58462 (/ISS)
Negative regulation of activated T cell proliferation GO:0046007
Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.
1 Q9BZS1 (/NAS)
Lung alveolus development GO:0048286
The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
1 P58463 (/IMP)
Embryonic foregut morphogenesis GO:0048617
The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase.
1 Q9DBY0 (/IMP)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 P58462 (/ISS)
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
1 Q9BZS1 (/IDA)
Negative regulation of immune response GO:0050777
Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
1 Q9BZS1 (/IDA)
Cardiac muscle cell differentiation GO:0055007
The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
1 P58462 (/IMP)
Righting reflex GO:0060013
A reflex process in which an animal immediately tries to turn over after being placed in a supine position.
1 P58463 (/IMP)
Regulation of cardiac muscle cell proliferation GO:0060043
Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation.
1 P58462 (/IGI)
Regulation of cardiac muscle cell proliferation GO:0060043
Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation.
1 P58462 (/IMP)
Positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501
Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.
1 P58463 (/IGI)
Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
1 P58462 (/ISS)
Negative regulation of cell growth involved in cardiac muscle cell development GO:0061052
Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
1 Q498D1 (/IMP)
Negative regulation of cell growth involved in cardiac muscle cell development GO:0061052
Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
1 P58462 (/ISO)
T follicular helper cell differentiation GO:0061470
The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell.
1 P58462 (/IDA)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q498D1 (/IEP)
Cardiovascular system development GO:0072358
The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels.
1 P58462 (/IGI)
Cardiovascular system development GO:0072358
The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels.
1 P58462 (/IMP)
Interleukin-21 secretion GO:0072619
The regulated release of interleukin-21 from a cell.
1 P58462 (/IDA)
Regulation of action potential GO:0098900
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 P58462 (/IMP)
Regulation of defense response to bacterium GO:1900424
Any process that modulates the frequency, rate or extent of defense response to bacterium.
1 P58462 (/ISS)
Regulation of macrophage colony-stimulating factor production GO:1901256
Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor production.
1 P58462 (/ISS)
Cellular response to ionomycin GO:1904637
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus.
1 Q498D1 (/IDA)
Cellular response to ionomycin GO:1904637
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus.
1 P58462 (/ISO)
Positive regulation of hydrogen peroxide-induced cell death GO:1905206
Any process that activates or increases the frequency, rate or extent of cell death in response to hydrogen peroxide.
1 Q498D1 (/IMP)
Positive regulation of hydrogen peroxide-induced cell death GO:1905206
Any process that activates or increases the frequency, rate or extent of cell death in response to hydrogen peroxide.
1 P58462 (/ISO)
Negative regulation of T-helper 17 cell differentiation GO:2000320
Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.
1 Q9BZS1 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
28 A0A0B4J2F3 (/IDA) A0A0B4J2F3 (/IDA) A0A0C4DFW6 (/IDA) B7ZLG1 (/IDA) H0Y882 (/IDA) Q548T7 (/IDA) Q548T7 (/IDA) Q548T7 (/IDA) Q548T7 (/IDA) Q548T7 (/IDA)
(18 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
17 E3VW73 (/IDA) P58462 (/IDA) Q498D1 (/IDA) Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA) Q9H334 (/IDA)
(7 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
12 Q9BZS1 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS) Q9H334 (/TAS)
(2 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 A0A060XHH6 (/ISS) A4IFD2 (/ISS) E4W7U4 (/ISS) E4W7U5 (/ISS) Q2LEZ0 (/ISS) Q498D1 (/ISS) Q6BBQ1 (/ISS) Q6U8D7 (/ISS) Q6U8D7 (/ISS) Q99JB6 (/ISS)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q498D1 (/IDA) Q99JB6 (/IDA) Q99JB6 (/IDA) Q9BZS1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P58462 (/ISO) Q99JB6 (/ISO) Q99JB6 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q4VYR7 (/NAS) Q4VYS1 (/NAS) Q5W1J5 (/NAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P58462 (/ISO) Q99JB6 (/ISO) Q99JB6 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
3 K4EPC4 (/IDA) Q6QBA5 (/IDA) Q6TKS2 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
3 A0A060XHH6 (/ISS) E4W7U4 (/ISS) E4W7U5 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q99JB6 (/ISO) Q99JB6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q6U8D7 (/ISS) Q6U8D7 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P58462 (/IC)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9BZS1 (/NAS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 E3VW73 (/IDA)
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