CATH Domain 6n9aD02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.40	ATPase, nucleotide binding domain

Domain Context

CATH Clusters

Superfamily	3.30.420.40
Functional Family	tRNA N6-adenosine threonylcarbamoyltransferase

Enzyme Information

2.3.1.234

N(6)-L-threonylcarbamoyladenine synthase.

based on mapping to UniProt Q9WXZ2

L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L- threonylcarbamoyladenine(37) in tRNA.

-!- The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg). -!- Formerly EC 2.6.99.4.

UniProtKB Entries (1)

Q9X1W7

Q9X1W7_THEMA

Thermotoga maritima MSB8

Uncharacterized protein

PDB Structure

PDB	6N9A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Conformational communication mediates the reset step in t6A biosynthesis. Luthra, A., Paranagama, N., Swinehart, W., Bayooz, S., Phan, P., Quach, V., Schiffer, J.M., Stec, B., Iwata-Reuyl, D., Swairjo, M.A. Nucleic Acids Res.