CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.850 | Fumarylacetoacetate hydrolase; domain 2 |
|
3.90.850.10 | Fumarylacetoacetase-like, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Fumarylacetoacetase-like, C-terminal domain |
| Functional Family | Fumarylacetoacetate hydrolase domain-containing 1 |
Enzyme Information
| 4.1.1.112 |
Oxaloacetate decarboxylase.
based on mapping to UniProt Q6P587
Oxaloacetate = pyruvate + CO(2).
-!- The enzymes from the fish Gadus morhua (Atlantic cod) and the bacterium Micrococcus luteus prefer Mn(2+), while those from the bacteria Pseudomonas putida and Pseudomonas aeruginosa prefer Mg(2+). -!- Unlike EC 7.2.4.2, there is no evidence of the enzyme's involvement in Na(+) transport. -!- Formerly EC 4.1.1.3.
|
| 3.7.1.5 |
Acylpyruvate hydrolase.
based on mapping to UniProt Q6P587
A 3-acylpyruvate + H(2)O = a carboxylate + pyruvate.
-!- Acts on formylpyruvate, 2,4-dioxopentanoate, 2,4-dioxohexanoate and 2,4-dioxoheptanoate.
|
UniProtKB Entries (1)
| Q6P587 |
FAHD1_HUMAN
Homo sapiens
Acylpyruvase FAHD1, mitochondrial
|
PDB Structure
| PDB | 6FOG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for the bi-functionality of human oxaloacetate decarboxylase FAHD1.
Biochem. J.
|
