CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
Superfamily | P-loop containing nucleotide triphosphate hydrolases |
Functional Family | KRAS proto-oncogene, GTPase |
Enzyme Information
UniProtKB Entries (1)
Q07889 |
SOS1_HUMAN
Homo sapiens
Son of sevenless homolog 1
|
PDB Structure
PDB | 6D59 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem.
|