CATH Classification

Domain Context

CATH Clusters

Superfamily Son of sevenless (SoS) protein Chain: S domain 1
Functional Family son of sevenless homolog 1 isoform X1

Enzyme Information

UniProtKB Entries (1)

Q07889
SOS1_HUMAN
Homo sapiens
Son of sevenless homolog 1

PDB Structure

PDB 6D59
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
Hodges, T.R., Abbott, J.R., Little, A.J., Sarkar, D., Salovich, J.M., Howes, J.E., Akan, D.T., Sai, J., Arnold, A.L., Browning, C., Burns, M.C., Sobolik, T., Sun, Q., Beesetty, Y., Coker, J.A., Scharn, D., Stadtmueller, H., Rossanese, O.W., Phan, J., Waterson, A.G., McConnell, D.B., Fesik, S.W.
J. Med. Chem.
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