CATH Domain 6ckcB00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	Methylosome protein 50

Enzyme Information

UniProtKB Entries (1)

ANM5_HUMAN

Homo sapiens

Protein arginine N-methyltransferase 5

PDB Structure

PDB	6CKC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. Bonday, Z.Q., Cortez, G.S., Grogan, M.J., Antonysamy, S., Weichert, K., Bocchinfuso, W.P., Li, F., Kennedy, S., Li, B., Mader, M.M., Arrowsmith, C.H., Brown, P.J., Eram, M.S., Szewczyk, M.M., Barsyte-Lovejoy, D., Vedadi, M., Guccione, E., Campbell, R.M. ACS Med Chem Lett