CATH Classification

Domain Context

CATH Clusters

Superfamily Ras guanine-nucleotide exchange factors catalytic domain
Functional Family son of sevenless homolog 1 isoform X2

Enzyme Information

UniProtKB Entries (1)

P01112
RASH_HUMAN
Homo sapiens
GTPase HRas

PDB Structure

PDB 6BVM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
Abbott, J.R., Hodges, T.R., Daniels, R.N., Patel, P.A., Kennedy, J.P., Howes, J.E., Akan, D.T., Burns, M.C., Sai, J., Sobolik, T., Beesetty, Y., Lee, T., Rossanese, O.W., Phan, J., Waterson, A.G., Fesik, S.W.
J. Med. Chem.
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