CATH Domain 6bbuA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P23458

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P23458

JAK1_HUMAN

Homo sapiens

Tyrosine-protein kinase JAK1

PDB Structure

PDB	6BBU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. Vazquez, M.L., Kaila, N., Strohbach, J.W., Trzupek, J.D., Brown, M.F., Flanagan, M.E., Mitton-Fry, M.J., Johnson, T.A., TenBrink, R.E., Arnold, E.P., Basak, A., Heasley, S.E., Kwon, S., Langille, J., Parikh, M.D., Griffin, S.H., Casavant, J.M., Duclos, B.A., Fenwick, A.E., Harris, T.M., Han, S., Caspers, N., Dowty, M.E., Yang, X., Banker, M.E., Hegen, M., Symanowicz, P.T., Li, L., Wang, L., Lin, T.H., Jussif, J., Clark, J.D., Telliez, J.B., Robinson, R.P., Unwalla, R. J. Med. Chem.