CATH Domain 6b6aD00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family	Beta-lactamase

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P9WKD3

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P9WKD3

BLAC_MYCTU

Mycobacterium tuberculosis H37Rv

Beta-lactamase

PDB Structure

PDB	6B6A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography. Olmos, J.L., Pandey, S., Martin-Garcia, J.M., Calvey, G., Katz, A., Knoska, J., Kupitz, C., Hunter, M.S., Liang, M., Oberthuer, D., Yefanov, O., Wiedorn, M., Heyman, M., Holl, M., Pande, K., Barty, A., Miller, M.D., Stern, S., Roy-Chowdhury, S., Coe, J., Nagaratnam, N., Zook, J., Verburgt, J., Norwood, T., Poudyal, I., Xu, D., Koglin, J., Seaberg, M.H., Zhao, Y., Bajt, S., Grant, T., Mariani, V., Nelson, G., Subramanian, G., Bae, E., Fromme, R., Fung, R., Schwander, P., Frank, M., White, T.A., Weierstall, U., Zatsepin, N., Spence, J., Fromme, P., Chapman, H.N., Pollack, L., Tremblay, L., Ourmazd, A., Phillips, G.N., Schmidt, M. BMC Biol.

Network disruptions