CATH Domain 6b3sI00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.80	Alpha-Beta Horseshoe
	3.80.20	24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
	3.80.20.20	Receptor L-domain

Domain Context

CATH Clusters

Superfamily	Receptor L-domain
Functional Family	Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P00533

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00533

EGFR_HUMAN

Homo sapiens

Epidermal growth factor receptor

PDB Structure

PDB	6B3S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab Resistance. Bagchi, A., Haidar, J.N., Eastman, S.W., Vieth, M., Topper, M., Iacolina, M.D., Walker, J.M., Forest, A., Shen, Y., Novosiadly, R.D., Ferguson, K.M. Mol. Cancer Ther.