×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

1 keywords

CATH Domain 6apvD00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.2020  

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family Hypoxanthine-guanine phosphoribosyltransferase

Enzyme Information

2.4.2.8
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt Q07010
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.

UniProtKB Entries (1)

Q07010
HPRT_TRYBB
Trypanosoma brucei brucei
Hypoxanthine-guanine phosphoribosyltransferase

PDB Structure

PDB 6APV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.
Dolezelova, E., Teran, D., Gahura, O., Kotrbova, Z., Prochazkova, M., Keough, D., Spacek, P., Hockova, D., Guddat, L., Zikova, A.
PLoS Negl Trop Dis
CATH-Gene3D is a Global Biodata Core Resource Learn more...