CATH Domain 5wi6D02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Tryptase gamma 1

Enzyme Information

3.4.21.59

Tryptase.

based on mapping to UniProt Q15661

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.

-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

Q15661

TRYB1_HUMAN

Homo sapiens

Tryptase alpha/beta-1

PDB Structure

PDB	5WI6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Dual functionality of beta-tryptase protomers as both proteases and cofactors in the active tetramer. Maun, H.R., Liu, P.S., Franke, Y., Eigenbrot, C., Forrest, W.F., Schwartz, L.B., Lazarus, R.A. J. Biol. Chem.