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1 keywords

CATH Domain 5w8vB00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.2020  

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family Hypoxanthine phosphoribosyltransferase

Enzyme Information

2.4.2.8
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt P00492
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.

UniProtKB Entries (1)

P00492
HPRT_HUMAN
Homo sapiens
Hypoxanthine-guanine phosphoribosyltransferase

PDB Structure

PDB 5W8V
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.
Spacek, P., Keough, D.T., Chavchich, M., Dracinsky, M., Janeba, Z., Naesens, L., Edstein, M.D., Guddat, L.W., Hockova, D.
J. Med. Chem.
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