CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.25 | Alpha Horseshoe |
|
1.25.40 | Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat |
|
1.25.40.20 | Ankyrin repeat-containing domain |
Domain Context
CATH Clusters
| Superfamily | Ankyrin repeat-containing domain |
| Functional Family | Palmitoyltransferase |
Enzyme Information
| 2.3.1.225 |
Protein S-acyltransferase.
based on mapping to UniProt Q8IUH5
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
-!- The enzyme catalyzes the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity. -!- Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association.
|
UniProtKB Entries (1)
| P60880 |
SNP25_HUMAN
Homo sapiens
Synaptosomal-associated protein 25
|
PDB Structure
| PDB | 5W7J |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase.
Structure
|
