CATH Domain 5uklA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.287	Helix Hairpins
	1.10.287.1270

Domain Context

CATH Clusters

Superfamily	1.10.287.1270
Functional Family

Enzyme Information

2.7.11.15

[Beta-adrenergic-receptor] kinase.

based on mapping to UniProt P25098

ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.

-!- Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. -!- Does not act on casein or histones. -!- Inhibited by Zn(2+) and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14 and EC 2.7.11.16). -!- Formerly EC 2.7.1.126.

UniProtKB Entries (1)

P25098

ARBK1_HUMAN

Homo sapiens

Beta-adrenergic receptor kinase 1

PDB Structure

PDB	5UKL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. Waldschmidt, H.V., Homan, K.T., Cato, M.C., Cruz-Rodriguez, O., Cannavo, A., Wilson, M.W., Song, J., Cheung, J.Y., Koch, W.J., Tesmer, J.J., Larsen, S.D. J. Med. Chem.