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1 keywords

CATH Domain 5olnB01

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.970 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
Homologous Superfamily 1.20.970.10 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C

Domain Context

CATH Clusters

Superfamily Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Functional Family Pyrimidine-nucleoside phosphorylase

Enzyme Information

2.4.2.2
Pyrimidine-nucleoside phosphorylase.
based on mapping to UniProt P39142
(1) Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. (2) Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. (3) 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate.
-!- Unlike EC 2.4.2.3 and EC 2.4.2.4, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine. -!- The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction. -!- Formerly EC 2.4.2.23.

UniProtKB Entries (1)

P39142
PDP_BACSU
Bacillus subtilis subsp. subtilis str. 168
Pyrimidine-nucleoside phosphorylase

PDB Structure

PDB 5OLN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of pyrimidine-nucleoside phosphorylase from Bacillus subtilis in complex with imidazole and sulfate.
Balaev, V.V., Prokofev, I.I., Gabdoulkhakov, A.G., Betzel, C., Lashkov, A.A.
Acta Crystallogr F Struct Biol Commun
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