CATH Domain 5nx1A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	kallikrein-6 isoform X1

Enzyme Information

3.4.21.-

Serine endopeptidases.

based on mapping to UniProt Q92876

UniProtKB Entries (1)

A4_HUMAN

Homo sapiens

Amyloid-beta precursor protein

PDB Structure

PDB	5NX1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. Sananes, A., Cohen, I., Shahar, A., Hockla, A., De Vita, E., Miller, A.K., Radisky, E.S., Papo, N. J.Biol.Chem.