CATH Domain 5ml2B00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.50	Coagulation Factor XIII; Chain A, domain 1
	2.70.50.40	GMP phosphodiesterase, delta subunit

Domain Context

CATH Clusters

Superfamily	GMP phosphodiesterase, delta subunit
Functional Family	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

Enzyme Information

UniProtKB Entries (1)

PDE6D_HUMAN

Homo sapiens

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

PDB Structure

PDB	5ML2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A PDE6 delta-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Martin-Gago, P., Fansa, E.K., Klein, C.H., Murarka, S., Janning, P., Schurmann, M., Metz, M., Ismail, S., Schultz-Fademrecht, C., Baumann, M., Bastiaens, P.I., Wittinghofer, A., Waldmann, H. Angew. Chem. Int. Ed. Engl.