CATH Domain 5m7tB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.80	Glycosidases

Domain Context

CATH Clusters

Superfamily	Glycosidases
Functional Family	O-GlcNAcase BT_4395

Enzyme Information

3.2.1.169

Protein O-GlcNAcase.

based on mapping to UniProt O60502

(1) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine. (2) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.

-!- Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. -!- EC 2.4.1.155 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins.

UniProtKB Entries (1)

O60502

OGA_HUMAN

Homo sapiens

Protein O-GlcNAcase

PDB Structure

PDB	5M7T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and functional insight into human O-GlcNAcase. Roth, C., Chan, S., Offen, W.A., Hemsworth, G.R., Willems, L.I., King, D.T., Varghese, V., Britton, R., Vocadlo, D.J., Davies, G.J. Nat. Chem. Biol.