CATH Domain 5ls6E00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	Polycomb protein eed

Enzyme Information

UniProtKB Entries (1)

JARD2_HUMAN

Homo sapiens

Protein Jumonji

PDB Structure

PDB	5LS6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas. Vaswani, R.G., Gehling, V.S., Dakin, L.A., Cook, A.S., Nasveschuk, C.G., Duplessis, M., Iyer, P., Balasubramanian, S., Zhao, F., Good, A.C., Campbell, R., Lee, C., Cantone, N., Cummings, R.T., Normant, E., Bellon, S.F., Albrecht, B.K., Harmange, J.C., Trojer, P., Audia, J.E., Zhang, Y., Justin, N., Chen, S., Wilson, J.R., Gamblin, S.J. J. Med. Chem.