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1 keywords

CATH Domain 5kxaA02

CATH Classification

Level CATH Code Description
Class 4 Few Secondary Structures
Architecture 4.10 Irregular
Topology 4.10.410 Factor Xa Inhibitor
Homologous Superfamily 4.10.410.20  

Domain Context

CATH Clusters

Superfamily 4.10.410.20
Functional Family Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Enzyme Information

3.1.4.39
Alkylglycerophosphoethanolamine phosphodiesterase.
based on mapping to UniProt Q13822
1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine.
-!- Also acts on acyl and choline analogs.

UniProtKB Entries (1)

Q13822
ENPP2_HUMAN
Homo sapiens
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

PDB Structure

PDB 5KXA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.
Bain, G., Shannon, K.E., Huang, F., Darlington, J., Goulet, L., Prodanovich, P., Ma, G.L., Santini, A.M., Stein, A.J., Lonergan, D., King, C.D., Calderon, I., Lai, A., Hutchinson, J.H., Evans, J.F.
J. Pharmacol. Exp. Ther.
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