CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Dihydroorotate dehydrogenase |
Enzyme Information
| 1.3.1.14 |
Dihydroorotate dehydrogenase (NAD(+)).
based on mapping to UniProt Q9CFW8
(S)-dihydroorotate + NAD(+) = orotate + NADH.
-!- The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit. -!- The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. -!- Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
|
UniProtKB Entries (1)
| Q9CFW8 |
PYRDB_LACLA
Lactococcus lactis subsp. lactis Il1403
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
|
PDB Structure
| PDB | 5KSW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Isoleucine 74 Plays a Key Role in Controlling Electron Transfer Between Lactococcus lactis Dihydroorotate Dehydrogenase 1B Subunits
To Be Published
|
