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1 keywords

CATH Domain 5kchA01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.30 Roll
Topology 2.30.30 SH3 type barrels.
Homologous Superfamily 2.30.30.140  

Domain Context

CATH Clusters

Superfamily 2.30.30.140
Functional Family Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q15047
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q15047
SETB1_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase SETDB1

PDB Structure

PDB 5KCH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy
Tempel, W., Harding, R.J., Mader, P., Dobrovetsky, E., Walker, J.R., Brown, P.J., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Santhakumar, S., Structural Genomics Consortium (SGC)
To Be Published
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