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1 keywords

CATH Domain 5j5dA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.70 Aldolase class I

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family 4-hydroxy-tetrahydrodipicolinate synthase

Enzyme Information

4.3.3.7
4-hydroxy-tetrahydrodipicolinate synthase.
based on mapping to UniProt P9WP25
Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5- tetrahydro-(2S)-dipicolinate + H(2)O.
-!- Formerly EC 4.2.1.52.

UniProtKB Entries (1)

P9WP25
DAPA_MYCTU
Mycobacterium tuberculosis H37Rv
4-hydroxy-tetrahydrodipicolinate synthase

PDB Structure

PDB 5J5D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition of Mycobacterium tuberculosis dihydrodipicolinate synthase by alpha-ketopimelic acid and its other structural analogues
Shrivastava, P., Navratna, V., Silla, Y., Dewangan, R.P., Pramanik, A., Chaudhary, S., Rayasam, G., Kumar, A., Gopal, B., Ramachandran, S.
Sci Rep
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