CATH Domain 5idzB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.120	Enolase-like C-terminal domain

Domain Context

CATH Clusters

Superfamily	Enolase-like C-terminal domain
Functional Family	Enolase 1

Enzyme Information

4.2.1.11

Phosphopyruvate hydratase.

based on mapping to UniProt P09104

2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.

-!- Also acts on 3-phospho-D-erythronate.

UniProtKB Entries (1)

ENOG_HUMAN

Homo sapiens

Gamma-enolase

PDB Structure

PDB	5IDZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pomhex, a cell-permeable Enolase inhibitor for Collateral Lethality targeting of ENO1-deleted Glioblastoma Lin, Y.H., Satani, N., Hammoudi, N., Felini, F., Leonard, P.G., Maxwell, D., Link, T., Lee, G.R., Bosajou, A., Duoli, S., Marszalek, J.R., Sun, Y.T., McMurray, J., Mandal, P.J., DiFrancesco, M.E., Czako, B., Wang, A., Bornmann, W., DePinho, R.A., Muller, F.L. To Be Published