CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.2020 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.2020 |
| Functional Family | Orotate phosphoribosyltransferase |
Enzyme Information
| 2.4.2.10 |
Orotate phosphoribosyltransferase.
based on mapping to UniProt P9WHK9
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- The enzyme from higher eukaryotes also catalyzes the reaction listed as EC 4.1.1.23.
|
UniProtKB Entries (1)
| P9WHK9 |
PYRE_MYCTU
Mycobacterium tuberculosis H37Rv
Orotate phosphoribosyltransferase
|
PDB Structure
| PDB | 5HKL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.
Sci Rep
|
