CATH Domain 5fgkB01

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.472	Cyclin A; domain 1
	1.10.472.10	Cyclin-like

Domain Context

CATH Clusters

Superfamily	Cyclin-like
Functional Family	Putative cyclin-c

Enzyme Information

UniProtKB Entries (1)

CDK8_HUMAN

Homo sapiens

Cyclin-dependent kinase 8

PDB Structure

PDB	5FGK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. Mallinger, A., Schiemann, K., Rink, C., Stieber, F., Calderini, M., Crumpler, S., Stubbs, M., Adeniji-Popoola, O., Poeschke, O., Busch, M., Czodrowski, P., Musil, D., Schwarz, D., Ortiz-Ruiz, M.J., Schneider, R., Thai, C., Valenti, M., de Haven Brandon, A., Burke, R., Workman, P., Dale, T., Wienke, D., Clarke, P.A., Esdar, C., Raynaud, F.I., Eccles, S.A., Rohdich, F., Blagg, J. J.Med.Chem.