CATH Domain 5f91B02

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.200	Fumarase C; Chain A, domain 2
	1.20.200.10	Fumarase/aspartase (Central domain)

Domain Context

CATH Clusters

Superfamily	Fumarase/aspartase (Central domain)
Functional Family	Fumarate hydratase, mitochondrial

Enzyme Information

4.2.1.2

Fumarate hydratase.

based on mapping to UniProt P9WN92

(S)-malate = fumarate + H(2)O.

UniProtKB Entries (1)

FUMC_MYCTO

Mycobacterium tuberculosis CDC1551

Fumarate hydratase class II

PDB Structure

PDB	5F91
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site. Kasbekar, M., Fischer, G., Mott, B.T., Yasgar, A., Hyvonen, M., Boshoff, H.I., Abell, C., Barry, C.E., Thomas, C.J. Proc.Natl.Acad.Sci.USA