CATH Domain 5cr5B02

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.10	D-amino Acid Aminotransferase; Chain A, domain 2
	3.20.10.10	D-amino Acid Aminotransferase, subunit A, domain 2

Superfamily	D-amino Acid Aminotransferase, subunit A, domain 2
Functional Family	Branched-chain-amino-acid aminotransferase, mitochondrial

2.6.1.42

Branched-chain-amino-acid transaminase.

based on mapping to UniProt O15382

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.

-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.

BCAT2_HUMAN

Homo sapiens

Branched-chain-amino-acid aminotransferase, mitochondrial

PDB	5CR5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library. Deng, H., Zhou, J., Sundersingh, F.S., Summerfield, J., Somers, D., Messer, J.A., Satz, A.L., Ancellin, N., Arico-Muendel, C.C., Sargent Bedard, K.L., Beljean, A., Belyanskaya, S.L., Bingham, R., Smith, S.E., Boursier, E., Carter, P., Centrella, P.A., Clark, M.A., Chung, C.W., Davie, C.P., Delorey, J.L., Ding, Y., Franklin, G.J., Grady, L.C., Herry, K., Hobbs, C., Kollmann, C.S., Morgan, B.A., Pothier Kaushansky, L.J., Zhou, Q. Acs Med.Chem.Lett.