CATH Domain 4zx3A05

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.50	Zincin-like fold
	1.25.50.10	Peptidase M1, alanyl aminopeptidase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Peptidase M1, alanyl aminopeptidase, C-terminal domain
Functional Family	M1 family aminopeptidase

Enzyme Information

3.4.11.-

Aminopeptidases.

based on mapping to UniProt O96935

UniProtKB Entries (1)

AMP1_PLAFQ

Plasmodium falciparum FcB1/Columbia

M1 family aminopeptidase

PDB Structure

PDB	4ZX3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Drinkwater, N., Vinh, N.B., Mistry, S.N., Bamert, R.S., Ruggeri, C., Holleran, J.P., Loganathan, S., Paiardini, A., Charman, S.A., Powell, A.K., Avery, V.M., McGowan, S., Scammells, P.J. Eur.J.Med.Chem.