CATH Domain 4ysiA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.210	Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
	2.60.210.10	Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A

Domain Context

CATH Clusters

Superfamily	Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Functional Family	Ubiquitin carboxyl-terminal hydrolase 7

Enzyme Information

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt Q93009

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (2)

F5HF68	VIRF1_HHV8P Human herpesvirus 8 strain GK18 VIRF-1
Q93009	UBP7_HUMAN Homo sapiens Ubiquitin carboxyl-terminal hydrolase 7

PDB Structure

PDB	4YSI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of USP7 with a novel viral protein Chavoshi, S., Egorova, O., Lacdao, I.K., Farhadi, S., Sheng, Y., Saridakis, V. J.Biol.Chem.