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1 keywords

CATH Domain 4xt4A00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.430 Dihydrofolate Reductase, subunit A
Homologous Superfamily 3.40.430.10 Dihydrofolate Reductase, subunit A

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Possible bifunctional enzyme riboflavin biosynthesis protein ribD: diaminohydroxyphosphoribosylaminopyrimidine deaminase + 5-amino-6-(5-phosphoribosylamino)uracil reductase

Enzyme Information

UniProtKB Entries (1)

P71968
P71968_MYCTU
Mycobacterium tuberculosis H37Rv
Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc...

PDB Structure

PDB 4XT4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Cheng, Y.S., Sacchettini, J.C.
Biochemistry
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