CATH Domain 4x2tL01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.220	Leucine Aminopeptidase, subunit E; domain 1
	3.40.220.10	Leucine Aminopeptidase, subunit E, domain 1

Domain Context

CATH Clusters

Superfamily	Leucine Aminopeptidase, subunit E, domain 1
Functional Family	M17 leucyl aminopeptidase

Enzyme Information

UniProtKB Entries (1)

Q8IL11_PLAF7

Plasmodium falciparum 3D7

M17 leucyl aminopeptidase

PDB Structure

PDB	4X2T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17. Drinkwater, N., Bamert, R.S., Sivaraman, K.K., Paiardini, A., McGowan, S. Proteins