CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.650 | Cupin |
Domain Context
CATH Clusters
| Superfamily | Cupin |
| Functional Family | lysine-specific demethylase 2A isoform X1 |
Enzyme Information
| 1.14.11.27 |
[Histone H3]-dimetyl-L-lysine-36 demethylase.
based on mapping to UniProt P59997
[Protein]-N(6),N(6)-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O(2) = [protein]-L-lysine + 2 succinate + 2 formaldehyde + 2 CO(2).
-!- Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36. -!- Lysine residues exist in three methylation states (mono-, di- and trimethylated). -!- The enzyme preferentially demethylates the dimethyl form of Lys-36 (K36me2), which is its natural substrate, to form the monomethyl and unmethylated forms of Lys-36. -!- It can also demethylate the monomethyl- but not the trimethyl form of Lys-36.
|
UniProtKB Entries (2)
| P59997 |
KDM2A_MOUSE
Mus musculus
Lysine-specific demethylase 2A
|
| P68431 |
H31_HUMAN
Homo sapiens
Histone H3.1
|
PDB Structure
| PDB | 4TN7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
Genes Dev.
|
