CATH Domain 4rylA02

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.160	Hnrnp arginine n-methyltransferase1
	2.70.160.11	Hnrnp arginine n-methyltransferase1

Domain Context

CATH Clusters

Superfamily	Hnrnp arginine n-methyltransferase1
Functional Family	protein arginine N-methyltransferase 3 isoform X2

Enzyme Information

2.1.1.-

Methyltransferases.

based on mapping to UniProt O60678

UniProtKB Entries (1)

ANM3_HUMAN

Homo sapiens

Protein arginine N-methyltransferase 3

PDB Structure

PDB	4RYL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). Kaniskan, H.U., Szewczyk, M.M., Yu, Z., Eram, M.S., Yang, X., Schmidt, K., Luo, X., Dai, M., He, F., Zang, I., Lin, Y., Kennedy, S., Li, F., Dobrovetsky, E., Dong, A., Smil, D., Min, S.J., Landon, M., Lin-Jones, J., Huang, X.P., Roth, B.L., Schapira, M., Atadja, P., Barsyte-Lovejoy, D., Arrowsmith, C.H., Brown, P.J., Zhao, K., Jin, J., Vedadi, M. Angew.Chem.Int.Ed.Engl.