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1 keywords

CATH Domain 4raqD00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.2020  

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family Hypoxanthine phosphoribosyltransferase

Enzyme Information

2.4.2.8
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt P00492
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.

UniProtKB Entries (1)

P00492
HPRT_HUMAN
Homo sapiens
Hypoxanthine-guanine phosphoribosyltransferase

PDB Structure

PDB 4RAQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
Keough, D.T., Hockova, D., Janeba, Z., Wang, T.H., Naesens, L., Edstein, M.D., Chavchich, M., Guddat, L.W.
J.Med.Chem.
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