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1 keywords

CATH Domain 4qnwA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.70 Aldolase class I

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family NADPH dehydrogenase 1

Enzyme Information

1.3.1.100
Chanoclavine-I aldehyde reductase.
based on mapping to UniProt Q4WZ70
Dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + NADPH.
-!- The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. -!- The enzyme catalyzes the reduction of chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde. -!- This hydrolyzes spontaneously to form 6,8-dimethyl-6,7- didehydroergoline, which is converted to festuclavine by EC 1.5.1.44.

UniProtKB Entries (1)

Q4WZ70
EASA_ASPFU
Aspergillus fumigatus Af293
Chanoclavine-I aldehyde reductase easA

PDB Structure

PDB 4QNW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of an Aspergillus fumigatus old yellow enzyme (EasA) involved in ergot alkaloid biosynthesis.
Chilton, A.S., Ellis, A.L., Lamb, A.L.
Acta Crystallogr.,Sect.F
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