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CATH Classification

Domain Context

CATH Clusters

Superfamily ATP-grasp fold, B domain
Functional Family Phosphoribosylaminoimidazole-succinocarboxamide synthase

Enzyme Information

6.3.2.6
Phosphoribosylaminoimidazolesuccinocarboxamide synthase.
based on mapping to UniProt O57978
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate.
-!- Forms part of the purine biosynthesis pathway.

UniProtKB Entries (1)

O57978
PUR7_PYRHO
Pyrococcus horikoshii OT3
Phosphoribosylaminoimidazole-succinocarboxamide synthase

PDB Structure

PDB 4O84
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
SAICAR synthetase (Type-1) in complex with GMP
Manjunath, K., Jeyakanthan, J., Sekar, K.
To be Published
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