CATH Domain 4o02A02

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.1460	Integrin domains. Chain A, domain 2

Domain Context

CATH Clusters

Superfamily	Integrin domains. Chain A, domain 2
Functional Family	Integrin, alpha V

Enzyme Information

UniProtKB Entries (1)

ITB3_HUMAN

Homo sapiens

Integrin beta-3

PDB Structure

PDB	4O02
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Atomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex. Mahalingam, B., Van Agthoven, J.F., Xiong, J.P., Alonso, J.L., Adair, B.D., Rui, X., Anand, S., Mehrbod, M., Mofrad, M.R., Burger, C., Goodman, S.L., Arnaout, M.A. J.Biol.Chem.