CATH Domain 4n7eA03

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.60	Wheat Germ Agglutinin (Isolectin 2); domain 1
	3.30.60.270

Domain Context

CATH Clusters

Superfamily	3.30.60.270
Functional Family	Sortilin

Enzyme Information

UniProtKB Entries (1)

SORT_HUMAN

Homo sapiens

Sortilin

PDB Structure

PDB	4N7E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Schrder, T.J., Christensen, S., Lindberg, S., Langgard, M., David, L., Maltas, P.J., Eskildsen, J., Jacobsen, J., Tagmose, L., Simonsen, K.B., Biilmann Rnn, L.C., de Jong, I.E., Malik, I.J., Karlsson, J.J., Bundgaard, C., Egebjerg, J., Stavenhagen, J.B., Strandbygard, D., Thirup, S., Andersen, J.L., Uppalanchi, S., Pervaram, S., Kasturi, S.P., Eradi, P., Sakumudi, D.R., Watson, S.P. Bioorg.Med.Chem.Lett.