CATH Domain 4n4wA02

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1070	Rhopdopsin 7-helix transmembrane proteins
	1.20.1070.10	Rhodopsin 7-helix transmembrane proteins

Superfamily	Rhodopsin 7-helix transmembrane proteins
Functional Family	Smoothened, frizzled class receptor

Q99835	SMO_HUMAN Homo sapiens Smoothened homolog
Q0SXH8	Q0SXH8_SHIF8 Shigella flexneri 5 str. 8401 Cytochrome b(562)

PDB	4N4W
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Wang, C., Wu, H., Evron, T., Vardy, E., Han, G.W., Huang, X.P., Hufeisen, S.J., Mangano, T.J., Urban, D.J., Katritch, V., Cherezov, V., Caron, M.G., Roth, B.L., Stevens, R.C. Nat Commun