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CATH Domain 4mdhA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.110 L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homologous Superfamily 3.90.110.10 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family Malate dehydrogenase

Enzyme Information

1.1.1.37
Malate dehydrogenase.
based on mapping to UniProt P11708
(S)-malate + NAD(+) = oxaloacetate + NADH.
-!- Also oxidizes some other 2-hydroxydicarboxylic acids.

UniProtKB Entries (1)

P11708
MDHC_PIG
Sus scrofa
Malate dehydrogenase, cytoplasmic

PDB Structure

PDB 4MDH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution.
Birktoft, J.J., Rhodes, G., Banaszak, L.J.
Biochemistry
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