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1 keywords

CATH Domain 4m0eA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.1820 alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Acetylcholinesterase

Enzyme Information

3.1.1.7
Acetylcholinesterase.
based on mapping to UniProt P22303
Acetylcholine + H(2)O = choline + acetate.
-!- Acts on a variety of acetic esters. -!- Also catalyzes transacetylations.

UniProtKB Entries (1)

P22303
ACES_HUMAN
Homo sapiens
Acetylcholinesterase

PDB Structure

PDB 4M0E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility.
Cheung, J., Gary, E.N., Shiomi, K., Rosenberry, T.L.
ACS Med Chem Lett
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