CATH Domain 4kxkC02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

2.6.1.51	Serine--pyruvate transaminase. based on mapping to UniProt P21549 L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. -!- The liver enzyme may be identical with EC 2.6.1.44.
2.6.1.44	Alanine--glyoxylate transaminase. based on mapping to UniProt P21549 L-alanine + glyoxylate = pyruvate + glycine. -!- With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. -!- A second component also catalyzes the reaction of EC 2.6.1.51.

UniProtKB Entries (1)

PEX5_HUMAN

Homo sapiens

Peroxisomal targeting signal 1 receptor

PDB Structure

PDB	4KXK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes. Fodor, K., Wolf, J., Reglinski, K., Passon, D.M., Lou, Y., Schliebs, W., Erdmann, R., Wilmanns, M. Traffic