CATH Classification

Domain Context

CATH Clusters

Superfamily SIR2/SIRT2 'Small Domain'
Functional Family NAD-dependent deacetylase sirtuin-3, mitochondrial

Enzyme Information

3.5.1.-
In linear amides.
based on mapping to UniProt Q9NTG7

UniProtKB Entries (1)

Q9NTG7
SIR3_HUMAN
Homo sapiens
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

PDB Structure

PDB 4JSR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3.
Disch, J.S., Evindar, G., Chiu, C.H., Blum, C.A., Dai, H., Jin, L., Schuman, E., Lind, K.E., Belyanskaya, S.L., Deng, J., Coppo, F., Aquilani, L., Graybill, T.L., Cuozzo, J.W., Lavu, S., Mao, C., Vlasuk, G.P., Perni, R.B.
J.Med.Chem.
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